Left atrial sense or capture detection from coronary sinus

• US 8,306,622 B2
• Filed: 09/28/2010
• Issued: 11/06/2012
• Est. Priority Date: 10/28/2009
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Arcot-Krishnamurthy, Shantha, Shome, Shibaji, Dong, Yanting
• Primary Examiner(s): Getzow, Scott
• Application Number:
  US12/892,378
• Publication Number:
  US 20110098768A1
• Time in Patent Office: 770 Days
• Field of Search: 607 4- 28
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

A method and device to detect and compare changes in atrial rate and morphology can be used to identify left atrial sense and capture, such as from a quadripolar or other lead located in or around the coronary sinus.

Claims

1. A cardiac function management device comprising:

a pacing circuit comprising a coronary sinus pacing electrode configured to be inserted via a coronary sinus of a heart of a subject, the coronary sinus pacing electrode configured to pace a first atrial chamber;

a sensing circuit configured to sense an atrial depolarization associated with a different second atrial chamber;

a measurement circuit, coupled to the pacing circuit and the sensing circuit, the measurement circuit configured to;

perform a first measurement of a parameter of the second atrial chamber depolarization in the absence of pacing from the coronary sinus pacing electrode, wherein the second atrial chamber depolarization is sensed in the absence of pacing from the coronary sinus pacing electrode; and

perform a second measurement of the same parameter of the second atrial chamber depolarization in the presence of pacing from the coronary sinus pacing electrode, wherein the second atrial chamber depolarization is sensed in the presence of pacing from the coronary sinus pacing electrode; and

a controller circuit, coupled to the measurement circuit, the controller circuit configured to compare a change between the first and second measurements to a criterion, and when the change meets the criterion, to declare that the first atrial chamber has been captured by the pacing from the coronary sinus pacing electrode.

2. The device of claim 1, wherein the change between the first and second measurements comprises an increase in heart rate.

3. The device of claim 1, wherein the change between the first and second measurements comprises a change in a cardiac depolarization morphology characteristic.

4. The device of claim 1, wherein the change between the first and second measurements comprises a change in at least one of:

a P-wave duration, a P-wave vector direction, a P-wave amplitude, a P-wave slope, a P-wave power, a P-wave frequency content, a P-wave area, a P-wave morphological feature, a P-wave spatiotemporal characteristic, or a change in depolarization conduction time between the coronary sinus pacing electrode and an electrode associated with the second atrial chamber.

5. The device of claim 1, wherein the controller circuit is coupled to the pacing circuit and configured to vary an energy of paces delivered by the coronary sinus pacing electrode to determine a first atrial chamber capture threshold energy associated with the coronary sinus pacing electrode.

6. The device of claim 1, wherein the change between the first and second measurements comprises a change in heart rate and a change in a depolarization morphology characteristic.

7. The device of claim 1, comprising a coronary sinus sensing electrode, configured to be inserted via a coronary sinus of the heart of the subject, the coronary sinus sensing electrode configured to sense a cardiac depolarization;

wherein the measurement circuit is configured to measure a delay between the sensed second atrial chamber depolarization and the sensed cardiac depolarization sensed at the coronary sinus sensing electrode during the same cardiac cycle; and

wherein the controller circuit is configured to use information about the delay to determine whether the sensed cardiac depolarization is associated with the first atrial chamber.

8. The device of claim 7, wherein the coronary sinus sensing electrode and the coronary sinus pacing electrode are the same electrode.

9. The device of claim 7, wherein the controller circuit is configured to compare the delay to a specified threshold value, and when the delay is less than the specified threshold value, to declare that the sensed cardiac depolarization is associated with the first atrial chamber.

10. The device of claim 7, wherein the coronary sinus sensing electrode comprises first and second coronary sinus sensing electrodes located at different coronary sinus locations;

wherein the measurement circuit is configured to;

measure a first delay between the sensed second atrial chamber depolarization and the sensed cardiac depolarization sensed at the first coronary sinus sensing electrode during the same cardiac cycle; and

measure a second delay between the sensed second atrial chamber depolarization and the sensed cardiac depolarization sensed at the second coronary sinus sensing electrode during the same cardiac cycle; and

wherein the controller is configured to compare a change in the first delay relative to the second delay to determine whether the sensed cardiac depolarization is associated with the first atrial chamber.

11. A method comprising:

designating a first atrial chamber for pacing from a coronary sinus pacing electrode that has been inserted via a coronary sinus of a heart of a subject;

designating a different second atrial chamber for sensing an atrial depolarization associated with the second atrial chamber;

sensing a second atrial chamber depolarization in the absence of pacing from the coronary sinus pacing electrode, and performing a first measurement of a parameter of the second atrial chamber depolarization in the absence of pacing from the coronary sinus pacing electrode;

sensing the second atrial chamber depolarization in the presence of pacing from the coronary sinus pacing electrode, and performing a second measurement of the same parameter of the second atrial chamber depolarization in the presence of pacing from the coronary sinus pacing electrode; and

comparing a change between the first and second measurements to a criterion, and when the change meets the criterion, declaring that the first atrial chamber has been captured by the pacing from the coronary sinus pacing electrode.

12. The method of claim 11, wherein the change between the first and second measurements comprises an increase in heart rate.

13. The method of claim 11, wherein the change between the first and second measurements comprises a change in a cardiac depolarization morphology characteristic.

14. The method of claim 11, wherein the change between the first and second measurements comprises a change in at least one of:

a P-wave duration, a P-wave vector direction, a P-wave amplitude, a P-wave slope, a P-wave power, or a P-wave frequency content, a P-wave area, a P-wave morphological feature, a P-wave spatiotemporal characteristic, or a change in depolarization conduction time between the coronary sinus pacing electrode and an electrode associated with the second atrial chamber.

15. The method of claim 11, comprising varying an energy of paces delivered by the coronary sinus pacing electrode to determine a first atrial chamber capture threshold energy associated with the coronary sinus pacing electrode.

16. The method of claim 11, wherein the change between the first and second measurements comprises a change in heart rate and a change in a depolarization morphology characteristic.

17. The method of claim 11, comprising:

sensing a cardiac depolarization using a coronary sinus sensing electrode that has been inserted via a coronary sinus of the heart of the subject;

measuring a delay between the sensed second atrial chamber depolarization and the sensed cardiac depolarization sensed at the coronary sinus sensing electrode during the same cardiac cycle; and

using information about the delay to determine whether the sensed cardiac depolarization is associated with the first atrial chamber.

18. The method of claim 17, wherein the coronary sinus sensing electrode and the coronary sinus pacing electrode are the same electrode.

19. The method of claim 17, wherein using information about the delay includes comparing the delay to a specified threshold value, and when the delay is less than the specified threshold value, declaring that the sensed cardiac depolarization is associated with the first atrial chamber.

20. The method of claim 17, wherein sensing a cardiac depolarization using a coronary sinus electrode includes using first and second coronary sinus sensing electrodes located at different coronary sinus locations;

wherein measuring a delay includes;

measuring a first delay between the sensed second atrial chamber depolarization and the sensed cardiac depolarization sensed at the first coronary sinus sensing electrode during the same cardiac cycle; and

measuring a second delay between the sensed second atrial chamber depolarization and the sensed cardiac depolarization sensed at the second coronary sinus sensing electrode during the same cardiac cycle; and

wherein using information about the delay includes comparing a change in the first delay relative to the second delay to determine whether the sensed cardiac depolarization is associated with the first atrial chamber.