MEMS device and method for delivery of therapeutic agents
First Claim
Patent Images
1. An implantable electrolytic pump comprising:
- a first exterior surface shaped to fit on the curved contour of an eyeball;
a drug chamber for containing a liquid to be administered;
a refill port resealably puncturable by a needle to facilitate refilling of the drug chamber;
a cannula in fluid communication with the chamber, an end of the cannula being shaped to facilitate insertion thereof into the eyeball;
first and second electrodes; and
a membrane disposed above the electrodes, the membrane being configured to expand and contract with increases and decreases in pressure, activation of the electrodes causing creation of a gas within the chamber to thereby expand the membrane so that liquid is forced from the chamber into the cannula, wherein (i) the first electrode includes at least one central elongate portion and a plurality of elongations extending from the at least one central elongate portion, and (ii) the second electrode at least partially encircles the first electrode.
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Abstract
Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient'"'"'s eyeball.
104 Citations
24 Claims
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1. An implantable electrolytic pump comprising:
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a first exterior surface shaped to fit on the curved contour of an eyeball; a drug chamber for containing a liquid to be administered; a refill port resealably puncturable by a needle to facilitate refilling of the drug chamber; a cannula in fluid communication with the chamber, an end of the cannula being shaped to facilitate insertion thereof into the eyeball; first and second electrodes; and a membrane disposed above the electrodes, the membrane being configured to expand and contract with increases and decreases in pressure, activation of the electrodes causing creation of a gas within the chamber to thereby expand the membrane so that liquid is forced from the chamber into the cannula, wherein (i) the first electrode includes at least one central elongate portion and a plurality of elongations extending from the at least one central elongate portion, and (ii) the second electrode at least partially encircles the first electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 22, 23, 24)
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12. A method of delivering a therapeutic agent to a patient, the method comprising:
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providing a pump comprising (i) an exterior surface shaped to fit on the curved contour of an eyeball, (ii) a drug chamber containing a liquid to be administered, (iii) a cannula in fluid communication with the chamber, an end of the cannula being shaped to facilitate insertion thereof into the eyeball, (iv) first and second electrodes, (v) a flexible, corrugated membrane disposed above the electrodes, and (vi) a generally circular wall disposed between the first and second electrodes, the generally circular wall including at least one fluid passageway; placing the pump on the patient'"'"'s eyeball; inserting the end of the cannula into the eyeball; and energizing the electrodes to cause creation of a gas within the chamber to thereby expand the membrane so that liquid is forced from the chamber through the cannula and is administered to the patient'"'"'s eye, wherein (i) the first electrode includes at least one central elongate portion and a plurality of elongations extending from the at least one central elongate portion, and (ii) the second electrode at least partially encircles the first electrode. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification