Method and system for drug delivery to the eye

• US 8,308,707 B2
• Filed: 01/24/2011
• Issued: 11/13/2012
• Est. Priority Date: 01/09/2001
• Status: Expired due to Fees

• Current Assignee: Microchips Biotech, Inc. (Keratin Biosciences, Inc.)
• Original Assignee: MicroCHIPS Inc.
• Inventors: Santini, John T. Jr., Cima, Michael J., Langer, Robert S., Ausiello, Dennis, Sheppard, Norman F. Jr., Herman, Stephen J.
• Primary Examiner(s): Mehta, Bhisma
• Application Number:
  US13/012,426
• Publication Number:
  US 20110172587A1
• Time in Patent Office: 659 Days
• Field of Search: 604/890.1, 604/891.1, 604/19, 604/20, 604/500, 604/521, 604/65, 604/66, 604/93.01, 604/113
• US Class Current: 604/500
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: H01L 24/96 the devices being encapsulated in a common layer, e.g. neo-wafer or pseudo-wafer, said common layer being separable into individual assemblies after connecting
• CPC Class Codes: H01L 2924/00 Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/01004 Beryllium [Be]
• CPC Class Codes: H01L 2924/01005 Boron [B]
• CPC Class Codes: H01L 2924/01006 Carbon [C]
• CPC Class Codes: H01L 2924/01011 Sodium [Na]
• CPC Class Codes: H01L 2924/01013 Aluminum [Al]
• CPC Class Codes: H01L 2924/01015 Phosphorus [P]
• CPC Class Codes: H01L 2924/0102 Calcium [Ca]
• CPC Class Codes: H01L 2924/01027 Cobalt [Co]
• CPC Class Codes: H01L 2924/01033 Arsenic [As]
• CPC Class Codes: H01L 2924/01074 Tungsten [W]
• CPC Class Codes: H01L 2924/01075 Rhenium [Re]
• CPC Class Codes: H01L 2924/01079 Gold [Au]
• CPC Class Codes: H01L 2924/014 : Solder alloys
• CPC Class Codes: H01L 2924/12041 : LED
• CPC Class Codes: H01L 2924/12042 : LASER
• CPC Class Codes: H01L 2924/12043 : Photo diode
• CPC Class Codes: H01L 2924/14 : Integrated circuits
• CPC Class Codes: H01L 2924/1461 : MEMS
• CPC Class Codes: H01L 2924/19041 : being a capacitor
• CPC Class Codes: H01L 2924/19043 : being a resistor

Abstract

Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient'"'"'s eye.

Claims

1. A method of locally administering a drug to an eye of a patient, the method comprising:

implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug and being defined by one or more substrate materials, at least one of the one or more substrate materials being impermeable to the drug and impermeable to water and air; and

directing focused light to the implanted device, at a first time, to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the eye.

2. The method of claim 1, wherein the one or more substrate materials comprises a metal or a glass.

3. The method of claim 1, wherein the one or more substrate materials comprises a multi-laminate material.

4. The method of claim 1, wherein the drug contained in each reservoir is in a solid form.

5. The method of claim 1, further comprising directing focused light to the implanted device, at a second later time, to open a second one of the reservoirs and thereby permit the drug to diffuse from the second reservoir to the eye.

6. The method of claim 1, wherein the focused light is from an ophthalmic laser.

7. The method of claim 1, wherein the focused light is directed through the cornea of the eye.

8. The method of claim 1, wherein the drug comprises an angiogenesis inhibitor.

9. The method of claim 1, wherein the drug comprises a steroid.

10. The method of claim 1, wherein the drug is released from the first reservoir into intraocular fluid of the eye.

11. A method of selectively opening an implanted containment reservoir for controlled delivery of a drug to a patient, comprising:

implanting in an eye of the patient a medical device which comprises a substrate in which at least one reservoir is located, the at least one reservoir containing a release system which comprises the drug, the at least one reservoir being defined by one or more substrate materials, at least one of the one or more substrate materials being impermeable to the drug and impermeable to water and air; and

then

directing focused light from an ophthalmic laser toward the release system in the at least one reservoir to cause the drug to be released from the device to the eye.

12. The method of claim 11, wherein the substrate material comprises a metal or a glass.

13. The method of claim 11, wherein the drug contained in the at least one reservoir is in a solid form.

14. The method of claim 11, wherein the focused light is directed through the cornea of the eye.