Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease

• US 8,308,784 B2
• Filed: 08/23/2007
• Issued: 11/13/2012
• Est. Priority Date: 08/24/2006
• Status: Active Grant

• Current Assignee: Photothera IP Holdings, Inc., Pthera,Llc
• Original Assignee: Photothera IP Holdings, Inc.
• Inventors: Streeter, Jackson, De Taboada, Luis
• Primary Examiner(s): Johnson, III, Henry M
• Application Number:
  US11/844,205
• Publication Number:
  US 20080125836A1
• Time in Patent Office: 1,909 Days
• Field of Search: 128/898, 607 88- 94
• US Class Current: 607/88
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 2005/0645 Applicators worn by the patient
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0618 Psychological treatment
• CPC Class Codes: A61N 5/067 using laser light

Abstract

A method of treating a patient having neurologic function affected by Parkinson'"'"'s disease is provided. The method includes providing a patient having neurologic function affected by Parkinson'"'"'s disease. The method further includes delivering electromagnetic radiation noninvasively through the scalp and the skull of the patient to at least one portion of the brain of the patient. The light energy has a wavelength in the visible to near-infrared wavelength range, and the wavelength, power density, and amount of the light energy delivered to the at least one portion of the brain are sufficient to reduce the severity of symptoms of Parkinson'"'"'s disease in the patient.

Claims

1. A method of treating a subject having neurologic function affected by Parkinson'"'"'s disease, the method comprising:

identifying a subject having neurologic function affected by Parkinson'"'"'s disease; and

delivering electromagnetic radiation noninvasively through the scalp and the skull of the subject to at least one portion of the brain of the subject, the electromagnetic radiation having a wavelength in the visible to near-infrared wavelength range, wherein the wavelength, power density, and amount of the electromagnetic radiation delivered to the at least one portion of the brain are sufficient to reduce the severity of symptoms of Parkinson'"'"'s disease in the subject, wherein the power density of the electromagnetic radiation delivered to the at least one portion of the brain is at least 0.01 mW/cm², wherein delivering the electromagnetic radiation comprises;

identifying at least about 10 treatment sites on the subject'"'"'s scalp;

directing an electromagnetic radiation source to each of the treatment sites; and

propagating electromagnetic radiation from the source to each treatment site, the electromagnetic radiation having a wavelength within a range between about 800 nanometers and about 830 nanometer.

2. The method of claim 1, wherein identifying at least about 10 treatment sites comprises placing a support on the subject'"'"'s head, the support comprising indicia of locations of the treatment sites.

3. The method of claim 2, wherein the indicia comprise openings in the support.

4. The method of claim 1, wherein propagating electromagnetic radiation comprises sequentially propagating electromagnetic radiation at each treatment site one at a time.

5. The method of claim 1, wherein the at least one portion of the brain comprises an area identified using medical imaging as exhibiting neurodegeneration.

6. The method of claim 1, wherein the at least one portion of the brain comprises an area identified as being associated with a particular cognitive or motor function.

7. The method of claim 1, wherein delivering electromagnetic radiation noninvasively through the scalp and the skull of the subject to the at least one portion of the brain comprises delivering electromagnetic radiation to substantially the entire brain.

8. The method of claim 1, wherein the power density is between 0.01 mW/cm² and 100 mW/cm² at a depth of approximately 2 centimeters below the dura.

9. The method of claim 1, wherein the power density is at least 0.1 mW/cm² at a depth of approximately 2 centimeters below the dura.

10. The method of claim 1, wherein the wavelength is between about 630 nanometers and about 1064 nanometers.

11. A method of treating a subject having neurologic function affected by Parkinson'"'"'s disease, the method comprising:

identifying a subject having neurologic function affected by Parkinson'"'"'s disease; and

delivering electromagnetic radiation noninvasively through the scalp and the skull of the subject to at least one portion of the brain of the subject, the electromagnetic radiation having a wavelength in the visible to near-infrared wavelength range, wherein the wavelength, power density, and amount of the electromagnetic radiation delivered to the at least one portion of the brain are sufficient to reduce the severity of symptoms of Parkinson'"'"'s disease in the subject, wherein the power density of the electromagnetic radiation delivered to the at least one portion of the brain is at least 0.01 mW/cm², wherein the at least one portion of the brain comprises an area identified using medical imaging as exhibiting neurodegeneration.

12. The method of claim 11, wherein delivering electromagnetic radiation noninvasively through the scalp and the skull of the subject to the at least one portion of the brain comprises delivering electromagnetic radiation to substantially the entire brain.

13. The method of claim 11, wherein the power density is between 0.01 mW/cm² and 100 mW/cm² at a depth of approximately 2 centimeters below the dura.

14. The method of claim 11, wherein the power density is at least 0.1 mW/cm² at a depth of approximately 2 centimeters below the dura.

15. The method of claim 11, wherein the wavelength is between about 630 nanometers and about 1064 nanometers.

16. A method of treating a subject having neurologic function affected by Parkinson'"'"'s disease, the method comprising:

identifying a subject having neurologic function affected by Parkinson'"'"'s disease; and

delivering electromagnetic radiation noninvasively through the scalp and the skull of the subject to at least one portion of the brain of the subject, the electromagnetic radiation having a wavelength in the visible to near-infrared wavelength range, wherein the wavelength, power density, and amount of the electromagnetic radiation delivered to the at least one portion of the brain are sufficient to reduce the severity of symptoms of Parkinson'"'"'s disease in the subject, wherein the power density of the electromagnetic radiation delivered to the at least one portion of the brain is at least 0.01 mW/cm², wherein the at least one portion of the brain comprises an area identified as being associated with a particular cognitive or motor function.

17. The method of claim 16, wherein delivering electromagnetic radiation noninvasively through the scalp and the skull of the subject to the at least one portion of the brain comprises delivering electromagnetic radiation to substantially the entire brain.

18. The method of claim 16, wherein the power density is between 0.01 mW/cm² and 100 mW/cm² at a depth of approximately 2 centimeters below the dura.

19. The method of claim 16, wherein the power density is at least 0.1 mW/cm² at a depth of approximately 2 centimeters below the dura.

20. The method of claim 16, wherein the wavelength is between about 630 nanometers and about 1064 nanometers.