Methods for elevating neurotrophic agents
First Claim
1. A method of elevating, in a highly innervated tissue in a subject, the concentrations of at least one neurotrophin and at least one inhibitor of degradation of said neurotrophin, comprising:
- (a) introducing into a highly innervated tissue in a subject at least one neurotrophin to elevate a neurotrophin concentration of the at least one neurotrophin within the highly innervated tissue;
(b) introducing into the highly innervated tissue at least one inhibitor of degradation of the at least one neurotrophin to elevate an inhibitor concentration of the at least one inhibitor of degradation of said neurotrophin within the highly innervated tissue; and
(c) regulating the concentration of the neurotrophin over time, wherein regulating includes;
monitoring, with at least one implanted sensor device, the neurotrophin concentration to determine whether at least one desired neurotrophin concentration target level of the at least one neurotrophin is present; and
adding additional neurotrophin in a quantity sufficient to adjust the neurotrophin concentration toward the at least one desired neurotrophin concentration target level.
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Accused Products
Abstract
Methods and systems are described that release one or both of a neurotrophin and an inhibitor of the degradation of the neurotrophin within or in the vicinity of a highly innervated tissue. In some embodiments, the method includes regulating the release of the neurotrophin and the inhibitor of degradation over time. In some embodiments, the method includes monitoring the concentration of the neurotrophin over time. The system may include a device or multiple devices for the release of the neurotrophin and the inhibitor as well as a controller. In some embodiments the system may include a sensor device and/or an imaging device capable of detecting the concentration of the neurotrophin over time. The release of the neurotrophin and inhibitor of degradation may be part of a controlled release system and regulated over time.
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Citations
43 Claims
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1. A method of elevating, in a highly innervated tissue in a subject, the concentrations of at least one neurotrophin and at least one inhibitor of degradation of said neurotrophin, comprising:
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(a) introducing into a highly innervated tissue in a subject at least one neurotrophin to elevate a neurotrophin concentration of the at least one neurotrophin within the highly innervated tissue; (b) introducing into the highly innervated tissue at least one inhibitor of degradation of the at least one neurotrophin to elevate an inhibitor concentration of the at least one inhibitor of degradation of said neurotrophin within the highly innervated tissue; and (c) regulating the concentration of the neurotrophin over time, wherein regulating includes; monitoring, with at least one implanted sensor device, the neurotrophin concentration to determine whether at least one desired neurotrophin concentration target level of the at least one neurotrophin is present; and adding additional neurotrophin in a quantity sufficient to adjust the neurotrophin concentration toward the at least one desired neurotrophin concentration target level. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of elevating, in a highly innervated tissue in a subject, the concentrations of at least one neurotrophin and at least one inhibitor of degradation of said neurotrophin, comprising:
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(a) introducing into a highly innervated tissue in a subject at least one neurotrophin to elevate a neurotrophin concentration of the at least one neurotrophin within the highly innervated tissue; (b) introducing into the highly innervated tissue at least one inhibitor of degradation of the at least one neurotrophin to elevate an inhibitor concentration of the at least one inhibitor of degradation of said neurotrophin within the highly innervated tissue; and (c) regulating the concentration of said at least one inhibitor of degradation of the neurotrophin over time, wherein regulating includes; monitoring, with at least one implanted sensor device, the inhibitor concentration to determine whether at least one desired inhibitor concentration target level of the at least one inhibitor of degradation is present; and adding additional inhibitor of degradation in a quantity sufficient to adjust the inhibitor concentration toward the at least one desired inhibitor concentration target level. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. A method of elevating, in a highly innervated tissue in a subject, the concentrations of at least one neurotrophin and at least one inhibitor of degradation of said neurotrophin, comprising:
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(a) introducing into a highly innervated tissue in a subject at least one neurotrophin to elevate a neurotrophin concentration of the at least one neurotrophin within the highly innervated tissue; (b) introducing into the highly innervated tissue at least one inhibitor of degradation of the at least one neurotrophin to elevate an inhibitor concentration of the at least one inhibitor of degradation of said neurotrophin within the highly innervated tissue; and (c) regulating the concentration of said at least one inhibitor of degradation of the neurotrophin over time, wherein regulating includes; monitoring the inhibitor concentration to determine whether at least one desired inhibitor concentration target level of the at least one inhibitor of degradation is present; and adding additional inhibitor of degradation in a quantity sufficient to adjust the inhibitor concentration toward the at least one desired inhibitor concentration target level; and (d) regulating the concentration of the neurotrophin over time, wherein regulating includes; monitoring, with at least one implanted sensor device, the neurotrophin concentration to determine whether at least one desired neurotrophin concentration target level of the at least one neurotrophin is present; and adding additional neurotrophin in a quantity sufficient to adjust the neurotrophin concentration toward the at least one desired neurotrophin concentration target level.
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Specification