Method for making medical devices having antimicrobial coatings thereon
First Claim
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1. A method for preparing a medical device having a silver nano-particle-containing antimicrobial LbL coating thereon, comprising the steps of:
- (a) obtaining a medical device with a polyelectrolyte LbL coating thereon, wherein the polyelectrolyte LbL coating includes one or more bilayers of a negatively charged polyionic material having —
COOH groups and a positively charged polyionic material;
(b) immersing the medical device having the polyelectrolyte LbL coating in a solution containing silver ions for a period of time sufficient to replace a desired amount of H+ with silver ions; and
(c) autoclaving the medical device of step (b) to reduce the silver ions contained in the polyelectrolyte LbL coating to form silver nano-particles wherein the medical device having the silver nano-particle-containing antimicrobial LbL coating exhibits at least 50% inhibition of viable microorganisms.
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Abstract
The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
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Citations
4 Claims
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1. A method for preparing a medical device having a silver nano-particle-containing antimicrobial LbL coating thereon, comprising the steps of:
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(a) obtaining a medical device with a polyelectrolyte LbL coating thereon, wherein the polyelectrolyte LbL coating includes one or more bilayers of a negatively charged polyionic material having —
COOH groups and a positively charged polyionic material;(b) immersing the medical device having the polyelectrolyte LbL coating in a solution containing silver ions for a period of time sufficient to replace a desired amount of H+ with silver ions; and (c) autoclaving the medical device of step (b) to reduce the silver ions contained in the polyelectrolyte LbL coating to form silver nano-particles wherein the medical device having the silver nano-particle-containing antimicrobial LbL coating exhibits at least 50% inhibition of viable microorganisms. - View Dependent Claims (2, 3, 4)
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Specification