Systems and methods for improving heart rate kinetics in heart failure patients

• US 8,311,631 B2
• Filed: 08/21/2009
• Issued: 11/13/2012
• Est. Priority Date: 06/29/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Hopper, Donald, Yu, Yinghong, Dong, Yanting
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Ghand, Jennifer
• Application Number:
  US12/545,676
• Publication Number:
  US 20090312815A1
• Time in Patent Office: 1,180 Days
• Field of Search: 600/520, 607/9, 607/11, 607 17- 26
• US Class Current: 607/19
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient'"'"'s heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient'"'"'s heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient'"'"'s intrinsic heart rate based on a profile of the patient'"'"'s heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

Claims

1. An implantable device, comprising:

electrodes for electrically coupling to a patient'"'"'s heart;

an activity sensor configured to detect activity of the patient;

a physiologic sensor configured to measure physiologic demand of the patient;

memory configured to store patient profile data, the patient profile data comprising heart rate response data relative to varying workloads established for the patient; and

a processor coupled to the electrodes, activity sensor, physiologic sensor, and memory, the processor configured to determine onset of sustained patient activity and that a heart rate parameter of the patient has reached a steady-state in response to the sustained patient activity, the processor configured to determine a timing relationship between the onset of sustained patient activity and the heart rate parameter reaching the steady-state, and to one or both of initiate and change a pacing therapy based on a comparison of the timing relationship to a stored patient profile of the patient'"'"'s heart rate response to varying workloads indicating slow heart rate response to the sustained patient activity.

2. The device of claim 1, wherein the processor is configured to withhold the pacing therapy in response to the processor determining that the patient'"'"'s heart rate response to the sustained activity is not slow.

3. The device of claim 1, wherein the processor is configured to determine sustaining of the patient activity in response to sensing an output signal produced by the activity sensor indicative of sustained patient activity for a time duration exceeding a threshold ranging between about 30 seconds and about 6 minutes.

4. The device of claim 1, wherein the processor is configured to determine sustaining of the patient activity in response the patient'"'"'s stroke volume reaching a steady-state value in response to the activity.

5. The device of claim 1, wherein the processor is configured to determine sustaining of the patient activity in response to sensing an output signal produced by the activity sensor and the physiologic sensor, respectively.

6. The device of claim 1, wherein the activity sensor comprises an accelerometer and the physiologic sensor comprises a minute ventilation sensor or a pressure sensor.

7. The device of claim 1, wherein the processor is configured to adjust an upper rate limit of the pacing therapy based on the patient'"'"'s profile.

8. The device of claim 1, wherein the processor is configured to adjust one or both of an AV delay parameter and a VV delay parameter of the pacing therapy.

9. The device of claim 1, wherein the processor is configured to acquire patient profile data comprising one or both of the patient'"'"'s intrinsic heart rate and minute ventilation, and to store the patient profile data in the memory.

10. The device of claim 1, wherein the processor is configured to acquire patient profile data comprising mean heart rate response time data at varying activity levels, and to store the patient profile data in the memory.

11. The device of claim 1, wherein the processor determines slowness of the patient'"'"'s heart rate response based on patient profile data associated with an activity level of the profile corresponding to the patient'"'"'s actual activity level.

12. An implantable device, comprising:

electrodes for electrically coupling to a patient'"'"'s heart;

an activity sensor configured to detect activity of the patient;

a physiologic sensor configured to measure physiologic demand of the patient;

memory configured to store patient profile data, the patient profile data comprising heart rate response data relative to varying workloads established for the patient; and

a processor coupled to the electrodes, activity sensor, physiologic sensor, and memory, the processor configured to determine onset of sustained patient activity and whether the patient'"'"'s intrinsic heart rate response is slow during a kinetic phase of the onset of the sustained activity based on a timing relationship between the onset of sustained patient activity and a heart rate parameter reaching the steady-state in response to the sustained patient activity, the processor configured to initiate or change a pacing therapy to deliver pacing pulses at a rate above the patient'"'"'s intrinsic heart rate based at least in part on the patient profile data if the patient'"'"'s intrinsic heart rate response during the kinetic phase is determined by the processor to be slow.

13. The device of claim 12, wherein the processor is configured to initiate or change the pacing therapy to deliver pacing pulses at a rate sufficient to improve a chronotropic response of the patient to the sustained activity.

14. The device of claim 12, wherein the processor is configured to initiate or change the pacing therapy to deliver pacing pulses at a rate sufficient to improve a chronotropic response of the patient to the sustained activity without overpacing the patient.

15. The device of claim 12, wherein the processor is configured to initiate or change the pacing therapy to deliver pacing pulses at a rate that improves a patient'"'"'s chronotropic response of the patient at different levels of patient activity.

16. The device of claim 12, wherein the processor is configured to initiate or change the pacing therapy to deliver pacing pulses at a rate sufficient to increase the patient'"'"'s heart rate response for reaching a steady-state exercise level of the sustained activity.

17. The device of claim 12, wherein the processor is configured to determine onset of sustained patient activity by sensing that the patient has been active for a time duration exceeding a threshold ranging between about 30 seconds and about 6 minutes.

18. The device of claim 12, wherein the processor is configured to determine onset of sustained patient activity by sensing that the patient'"'"'s stroke volume has reached a steady-state value in response to the patient activity.

19. The device of claim 12, wherein the processor is configured adjust one or both of an AV delay parameter and a VV parameter of the pacing therapy to deliver pacing pulses at the rate above the patient'"'"'s intrinsic heart rate.

20. An implantable device, comprising:

means for determining onset of sustained patient activity;

means for determining that a heart rate parameter of the patient has reached a steady-state in response to the sustained patient activity;

means for determining a timing relationship between the onset of sustained patient activity and the heart rate parameter reaching the steady-state; and

means for one or both of initiating and changing a pacing therapy based on a comparison of the timing relationship to a profile of the patient'"'"'s heart rate response to varying workloads indicating slow heart rate response to the sustained patient activity.