Sampling device and method

• US 8,312,780 B2
• Filed: 06/25/2010
• Issued: 11/20/2012
• Est. Priority Date: 06/25/2010
• Status: Active Grant

• Current Assignee: Mettler Toledo GmbH
• Original Assignee: Mettler-Toledo AG (Mettler-Toledo International Inc.)
• Inventors: Blacklin, Peter Alfred, Fowler, Wayne Jr., Hawkins, Joel Michael, Ward, Howard William II
• Primary Examiner(s): Macchiarolo, Peter J
• Assistant Examiner(s): BELLAMY, TAMIKO D
• Application Number:
  US12/823,718
• Publication Number:
  US 20110314900A1
• Time in Patent Office: 879 Days
• Field of Search: 738/638.2, 738/646.3, 738/647.3, 738/646.4, 738/641.2, 738/64, 422/521, 422/119
• US Class Current: 73/863
• CPC Class Codes: B01L 3/021 Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
• CPC Class Codes: G01N 1/10 in the liquid or fluent state burettes, pipettes B01L3/02; sampling of ground water E02D1/06; metering by volume of fluids or fluent solid material G01F11/00, G01F13/00
• CPC Class Codes: G01N 1/14 Suction devices, e.g. pumps; Ejector devices
• CPC Class Codes: G01N 1/22 in the gaseous state specially adapted for biological material G01N33/497; measuring breath flow A61B5/087
• CPC Class Codes: G01N 2001/1427 Positive displacement, piston, peristaltic
• CPC Class Codes: G01N 2001/2057 Sample chamber in a valve/piston
• CPC Class Codes: G01N 30/02 Column chromatography

Abstract

An in situ autosampling method and associated sampling device for capturing a material sample from a vessel. Methods of the present invention make use of a sampling device having an extendable sample capture element with a concave sample capture pocket located near a distal end thereof. The sample capture pocket is adapted to capture a known volume of material when the sample capture element is extended into said material. The material sample remains trapped in the sample capture pocket upon sample capture element retraction. Ports in the sample capture pocket may be placed in communication with corresponding material transfer channels extending through the sample capture element to allow for the in situ processing of a material sample, and the subsequent discharge of the sample to an analyzer or another downstream location.

Claims

1. A method of capturing a sample of a material of interest, said method comprising:

providing a sampling device, said sampling device including a reciprocative sample capture element located within an outer tube and adapted for extension and retraction with respect thereto;

a sample capture pocket located near a distal end of said sample capture element, said sample capture pocket adapted to capture a volume of material and having a processing material receiving port and a material expulsion port therein, said ports in communication with corresponding channels in said sample capture element when said sample capture element is in a retracted position; and

sampling lines leading from said channels in said sample capture element;

positioning a sampling end of said sampling device in or near a sample of a material of interest;

causing said sample capture element of said sampling device to extend from said outer tube into said material of interest, thereby filling said sample capture pocket in said sample capture element with an amount of said material;

causing said sample capture element of said sampling device to retract into said outer tube, thereby trapping a sample of said material of interest in said sample capture pocket;

processing said sample of material in situ within said sample capture pocket; and

discharging said sample of material from said sample capture pocket to a downstream location.

2. The method of claim 1, further comprising purging said sampling lines and said sample capture pocket before extending said sample capture element into a material of interest.

3. The method of claim 1, wherein the processing of said sample of material trapped in said sample capture pocket includes quenching said sample by passing a quenching fluid thereto via said processing material receiving port.

4. The method of claim 1, wherein the processing of said sample of material trapped in said sample capture pocket includes diluting said sample by passing a dilution material thereto via said processing material receiving port.

5. The method of claim 4, wherein a specified amount of dilution material is cyclically pumped through said sample of material prior to the discharge of said sample of material by a dilution material.

6. The method of claim 4, wherein a continuous flow of dilution material is used to dilute and discharge said sample of material.

7. The method of claim 4, wherein said dilution material is selected from the group consisting of a gas, a liquid solvent, and a neutral liquid.

8. The method of claim 1, further comprising passing a quenching fluid through said sampling lines of said sampling device while said sample capture element thereof is extended into a material of interest.

9. The method of claim 8, wherein said quenching fluid is circulated through said sampling lines via a by-pass port in said sample capture element.

10. The method of claim 1, further comprising using a vacuum pump to discharge or assist with discharging said sample of material.

11. The method of claim 1, wherein a sample of material is discharged to an analyzer selected from the group consisting of a gas chromatograph, a HPLC device, and a combination thereof.

12. The method of claim 1, wherein said sampling device is an autosampling device, and wherein operating commands are sent to said autosampling device by a microprocessor-based controller associated with another device used to control or analyze a material of interest.

13. The method of claim 12, further comprising monitoring one or more steps of a sample capture operation for completion and awaiting confirmation of completion before proceeding to a subsequent step.

14. The method of claim 1, wherein said sample capture element is extended and retracted by a powered linear actuator.

15. The method of claim 1, wherein said sample capture element is manually extended and retracted by a user of said device.

26. The method of claim 1, wherein a sample of material is discharged to an analyzer selected from the group consisting of a gas chromatograph, a HPLC device, and a combination thereof.

16. A method of capturing a sample of a material of interest, said method comprising:

providing an autosampling device, said autosampling device including a reciprocative sample capture element located within an outer tube and adapted for extension and retraction with respect thereto;

a sample capture pocket located near a distal end of said sample capture element, said sample capture pocket adapted to capture a volume of material when extended and to trap said volume of material when retracted, said sample capture pocket having a port for receiving processing material therein and a port for expelling material therefrom, said ports in communication with corresponding channels in said sample capture element when said sample capture element is in a retracted position; and

sampling lines leading from said channels in said sample capture element;

connecting said autosampling device to an actuator adapted to produce a selective extension and retraction of said sample capture element;

positioning a sampling end of said autosampling device in or over a sample of a material of interest;

activating said actuator to cause said sample capture element of said autosampling device to extend from said outer tube into said material of interest, thereby filling said sample capture pocket in said sample capture element with an amount of said material;

activating said actuator to cause said sample capture element of said autosampling device to retract into said outer tube, thereby trapping a sample of said material of interest in said sample capture pocket;

processing said sample of material in said sample capture pocket by passing a processing material thereto via a sampling line, a corresponding channel in said sample capture element, and a processing material receiving port in said sample capture pocket; and

discharging said sample of material from said sample capture pocket to a downstream location via an expulsion port in said sample capture pocket, a corresponding channel in said sample capture element, and a sampling line connected thereto.

17. The method of claim 16, further comprising purging said sampling lines and said sample capture pocket before extending said sample capture element into a material of interest.

18. The method of claim 16, wherein the processing of said sample of material trapped in said sample capture pocket includes quenching said sample by passing a quenching fluid thereto via said processing material receiving port.

19. The method of claim 16, wherein the processing of said sample of material trapped in said sample capture pocket includes diluting said sample by passing a dilution material thereto via said processing material receiving port.

20. The method of claim 19, wherein a specified amount of dilution material is cyclically pumped through said sample of material prior to the discharge of said sample of material by a dilution material.

21. The method of claim 19, wherein a continuous flow of dilution material is used to dilute and discharge said sample of material.

22. The method of claim 19, wherein said dilution material is selected from the group consisting of a gas, a liquid solvent, and a neutral liquid.

23. The method of claim 16, further comprising circulating a quenching fluid through said sampling lines of said sampling device while said sample capture element thereof is extended into a material of interest.

24. The method of claim 23, wherein said quenching fluid is circulated through said sampling lines via a by-pass port in said sample capture element.

25. The method of claim 16, further comprising using a vacuum pump to discharge or assist with discharging said sample of material.

27. A sampling device for capturing a sample of a material of interest, said device comprising:

a reciprocative sample capture element located within an outer tube and adapted for extension and retraction with respect thereto;

a sample capture pocket located near a distal end of said sample capture element, said sample capture pocket adapted to capture a volume of material;

a processing material receiving port located in said sample capture pocket;

a material expulsion port located in said sample capture pocket;

corresponding channels in said sample capture element, said channels in communication with said ports when said sample capture element is in a retracted position;

a sampling line leading from a channel in said sample capture element to at least one supply of processing material to supply processing material to said sample capture pocket for the in situ processing of a material sample; and

a sampling line leading from a channel in said sample capture element to at least one downstream vessel for receiving material expelled from said sample capture pocket.

28. The sampling device of claim 27, wherein said channels in said sample capture element are internal thereto.

29. The sampling device of claim 27, wherein said channels in said sample capture element extend along the external surface thereof.

30. The sampling device of claim 27, wherein said device is an autosampling device and said actuator is a powered linear actuator.

31. The sampling device of claim 27, wherein said device is a manual sampling device and said sample capture element is manually extended and retracted by a user of said device.