Device and machine for regenerating a human liver

• US 8,313,452 B2
• Filed: 03/17/2011
• Issued: 11/20/2012
• Est. Priority Date: 04/18/2003
• Status: Expired due to Fees

• Current Assignee: Bellco SRL (Medtronic Plc)
• Original Assignee: Bellco SRL (Medtronic Plc)
• Inventors: Franco Nardo, Bruno Pasquale, Cavallari, Antonino, Cianciavicchia, Domenico
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): HAYMAN, IMANI N
• Application Number:
  US13/050,044
• Publication Number:
  US 20110166493A1
• Time in Patent Office: 614 Days
• Field of Search: 604/6.14, 604/8, 604/500, 604507-509, 604/6.11, 604/6.13
• US Class Current: 604/6.14
• CPC Class Codes: A61M 1/3496 Plasmapheresis; Leucopheresis; Lymphopheresis A61M1/3472 takes precedence
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation

Abstract

A method of assisting in regenerating a patient'"'"'s liver includes fluidly coupling a first end of a conduit with a first blood vessel of the patient that carries oxygenated blood. A second end of the conduit is fluidly coupled with a second blood vessel of the patient that carries blood to the patient'"'"'s liver. Oxygenated blood is allowed to flow from the first blood vessel, through the conduit and to the liver via the second blood vessel of the patient.

Claims

1. A method of assisting in regenerating a patient'"'"'s liver, the method comprising steps of:

fluidly coupling a first catheter with an artery of the patient;

fluidly coupling a second catheter with the patient'"'"'s portal vein;

fluidly coupling an extracorporeal circuit between the first catheter and the second catheter such that blood exiting the artery of the patient passes through the first catheter, through the extracorporeal circuit and returns to the patient'"'"'s portal vein and into the patient'"'"'s liver through the second catheter;

monitoring at least one of a hematocrit and a partial pressure of molecular oxygen in the blood flowing through the extracorporeal circuit; and

using feedback control to regulate how much oxygen is provided to an oxygenator configured to provide oxygen to the blood flowing through the extracorporeal circuit.

2. The method of claim 1, wherein fluidly coupling the second catheter with the patient'"'"'s portal vein comprises steps of:

advancing a wire guide through the patient'"'"'s right jugular vein, inferior vena cava and right suprahepatic vein;

advancing the second catheter over the wire guide; and

removing the wire guide.

3. The method of claim 1, wherein the extracorporeal circuit further comprises a heater.

4. The method of claim 1, wherein the extracorporeal circuit further comprises a hemofilter.

5. The method of claim 1, wherein the extracorporeal circuit further comprises a drip chamber.

6. The method of claim 1, wherein the extracorporeal circuit further comprises a pump.

7. The method of claim 1, wherein the extracorporeal circuit further comprises a blood oxygen sensor.