Methods and devices for treatment of migraines

• US 8,313,520 B2
• Filed: 12/08/2011
• Issued: 11/20/2012
• Est. Priority Date: 05/13/2005
• Status: Active Grant

• Current Assignee: Braincool Ab, Temple University of The Commonwealth System of Higher Education
• Original Assignee: Benechill, Inc. (Braincool Ab)
• Inventors: Barbut, Denise, Rozenberg, Allan
• Primary Examiner(s): Gibson, Roy
• Assistant Examiner(s): SMITH, KAITLYN ELIZABETH
• Application Number:
  US13/315,141
• Publication Number:
  US 20120083764A1
• Time in Patent Office: 348 Days
• Field of Search: 607/113, 607/1, 607/96, 607/104, 607/105
• US Class Current: 607/113
• CPC Class Codes: A61F 2007/0065 Causing evaporation
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61F 7/123 using a flexible balloon containing the thermal element
• CPC Class Codes: A61K 31/02 Halogenated hydrocarbons
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 15/085 Fixing means therefor
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0409 with mean for closing the oesophagus
• CPC Class Codes: A61M 16/0438 Liquid-filled
• CPC Class Codes: A61M 16/0443 Special cuff-wall materials A61M16/0481, A61M16/0422 take precedence
• CPC Class Codes: A61M 16/0459 one cuff behind another
• CPC Class Codes: A61M 16/0461 Nasoendotracheal tubes
• CPC Class Codes: A61M 16/0479 above the cuff, e.g. giving access to the upper trachea
• CPC Class Codes: A61M 16/0486 Multi-lumen tracheal tubes
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/209 Relief valves
• CPC Class Codes: A61M 19/00 Local anaesthesia syringes therefor A61M5/00; Hypothermia A61M5/42 takes precedence; cooling blood in a bypass of the arterial system A61M1/36
• CPC Class Codes: A61M 2016/0027 : pressure meter
• CPC Class Codes: A61M 2025/0034 : characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores
• CPC Class Codes: A61M 2025/0036 : with more than four lumina
• CPC Class Codes: A61M 2025/0073 : Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
• CPC Class Codes: A61M 2202/0275 : Nitric oxide [NO]
• CPC Class Codes: A61M 2205/3606 : cooled
• CPC Class Codes: A61M 25/003 : characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves catheter tips A61M25/0067
• CPC Class Codes: A61M 25/0032 : characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
• CPC Class Codes: A61M 25/0068 : Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/007 : Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/1011 : Multiple balloon catheters
• CPC Class Codes: A61M 31/00 : Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methods for treating a migraine by cooling a patient'"'"'s nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient'"'"'s nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A liquid having a temperature between about −20° C. and about 37° C. is infused through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an elongate member having a plurality of ports is inserted into the nasal cavity. A perfluorocarbon spray and a gas are then delivered onto a surface of the nasal cavity through the plurality of ports.

Claims

1. A method for treating a migraine, comprising the steps of:

selecting a patient suffering from a migraine;

inserting an elongate member into a nasal cavity of the patient through the patient'"'"'s nostril, the elongate member having a proximal end, a distal end, a first lumen extending therebetween, and a plurality of ports in fluid communication with the first lumen; and

cooling the patient'"'"'s nasopharyngeal cavity to treat the migraine, wherein the step of cooling comprises delivering a nebulized liquid and a gas onto a surface of the patient'"'"'s nasal cavity through the plurality of ports,

wherein the liquid is nebulized at the plurality of ports within the nasal cavity, wherein the liquid evaporates at body temperature, and wherein the gas enhances evaporation of the liquid from the nasal cavity.

2. The method of claim 1, further comprising the step of delivering a drug to the patient.

3. The method of claim 2, wherein the drug is delivered onto a surface of the patient'"'"'s nasal cavity.

4. The method of claim 2, wherein the drug is sumatriptan.

5. The method of claim 1, wherein the nebulized liquid has a boiling point above 37°

C.

6. The method of claim 5, wherein the nebulized liquid has a boiling point between about 38-300°

C.

7. The method of claim 5, wherein the nebulized liquid has a boiling point between about 38-200°

C.

8. The method of claim 5, wherein the nebulized liquid has a boiling point between about 60-150°

C.

9. The method of claim 1, wherein the nebulized liquid is a perfluorocarbon.

10. The method of claim 9, wherein the perfluorocarbon liquid comprises perfluorocarbon 2-methyl perfluoropentane.

11. The method of claim 9, perfluorocarbon liquid comprises perfluorohexane.

12. The method of claim 1, wherein the gas is oxygen.

13. The method of claim 1, wherein cooling the nasopharyngeal cavity reduces the cerebral temperature of the patient by at least 1°

C. in one hour.