Multilayered optical sensing patch and retaining plug therefor
First Claim
1. A multilayered optical sensing patch comprising:
- (a) a heat sealable polymer substrate layer comprised of one or more of a polyether, polyamide or polyolefin; and
having an optical transparency of 50% or greater over the spectral range of interest and a processing temperature of 180°
C. or less;
(b) a polymeric sensing membrane layer heat sealed to said heat sealable polymer substrate layer said polymeric sensing membrane layer, comprised of;
(i) a porous polymer support membrane layer having been subjected to a pretreatment, said pretreatment allowing the porous polymer support membrane to withstand a heat sealing process in which both layers are heated to a temperature higher than an onset melting point of the heat polymer substrate sealable layer, but lower than a melt temperature of the polymeric sensing membrane layer;
said porous polymer support membrane having a plurality of pores disposed therein;
said porous polymer support membrane consisting of nylon, polyester, or nitrocellulose having a pore size of from about 0.1 to about 20 μ
m and an onset melt temperature of 200°
C. or greater,(ii) an optical sensing composition comprising a reactive indicator covalently bonded to chemical groups on the porous polymer support membrane, said optical sensing composition comprising a fluorescent or colorimetric sensing composition for the detection or measurement of oxygen, pH, carbon dioxide, ammonia, alkali, and alkaline-earth metal ions, or metabolites;
the reactive indicator being covalently bonded to free amines or amino groups on a surface of the porous polymer support membrane.
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Abstract
A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.
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Citations
7 Claims
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1. A multilayered optical sensing patch comprising:
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(a) a heat sealable polymer substrate layer comprised of one or more of a polyether, polyamide or polyolefin; and
having an optical transparency of 50% or greater over the spectral range of interest and a processing temperature of 180°
C. or less;(b) a polymeric sensing membrane layer heat sealed to said heat sealable polymer substrate layer said polymeric sensing membrane layer, comprised of; (i) a porous polymer support membrane layer having been subjected to a pretreatment, said pretreatment allowing the porous polymer support membrane to withstand a heat sealing process in which both layers are heated to a temperature higher than an onset melting point of the heat polymer substrate sealable layer, but lower than a melt temperature of the polymeric sensing membrane layer;
said porous polymer support membrane having a plurality of pores disposed therein;
said porous polymer support membrane consisting of nylon, polyester, or nitrocellulose having a pore size of from about 0.1 to about 20 μ
m and an onset melt temperature of 200°
C. or greater,(ii) an optical sensing composition comprising a reactive indicator covalently bonded to chemical groups on the porous polymer support membrane, said optical sensing composition comprising a fluorescent or colorimetric sensing composition for the detection or measurement of oxygen, pH, carbon dioxide, ammonia, alkali, and alkaline-earth metal ions, or metabolites;
the reactive indicator being covalently bonded to free amines or amino groups on a surface of the porous polymer support membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification