System and method for three-dimensional imaging using scattering from annihilation coincidence photons

• US 8,314,394 B1
• Filed: 11/04/2010
• Issued: 11/20/2012
• Est. Priority Date: 11/04/2009
• Status: Active Grant

• Current Assignee: Leidos, Inc. (Leidos Holdings, Inc.)
• Original Assignee: Science Applications International Corporation
• Inventors: Penny, Robert David, Valentine, John D.
• Primary Examiner(s): Kim, Kiho
• Application Number:
  US12/939,449
• Time in Patent Office: 747 Days
• Field of Search: 25036301-3631
• US Class Current: 250/363.03
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: G01T 1/1647 Processing of scintigraphic data not related to a particular imaging system G01T1/2992
• CPC Class Codes: G01T 1/2985 In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); using external radiation sources A61B6/02

Abstract

Systems and methods are described herein for performing three-dimensional imaging using backscattered photons generated from a positron-electron annihilation. The systems and methods are implemented using the pair of photons created from a positron-electron annihilation. The trajectory and emission time of one of the photons is detected near the annihilation event. Using this collected data, the trajectory of the second photon can be determined. The second photon is used as a probe photon and is directed towards a target for imaging. The interaction of the second probe photon with the target produces back scattered photons that can be detected and used to create a three-dimensional image of the target. The systems and methods described herein are particularly advantageous because they permit imaging with a system from a single side of the target, as opposed to requiring imaging equipment on both sides of the target.

Claims

1. A method for creating an image of a target, the method comprising:

arranging a radioisotope source that emits positrons that collide with electrons, the collision emitting a first photon and a second photon;

measuring by a gamma detector a first trajectory and a first time associated with the first photon;

calculating by an imaging software module installed on a computer a second time and a second trajectory associated with the second photon;

detecting by an imaging detector a scattered photon created from a collision between the second photon and a target, the imaging detector measuring a scattered trajectory and a scattered time associated with the scattered photon; and

calculating by the imaging software module a position of the target based on the second time, the second trajectory, the scattered time and the scattered trajectory.

2. The method of claim 1, wherein the imaging detector is a coded aperture imager comprising an array of detectors and a patterned mask.

3. The method of claim 1, wherein the radioisotope source and the imaging detector are located on one side of the target such that the angle between the second trajectory of the second photon and the scattered trajectory of the scattered photon is less than 180 degrees.

4. The method of claim 1, further comprising the step of the imaging software module filtering a second scattered photon based on a second scattered time associated with the second scattered photon.

5. The method of claim 1, further comprising the step of the imaging software module filtering a second scattered photon based on a second energy level associated with the second scattered photon.

6. The method of claim 1, further comprising the step of opening a first window and a second window in a source holder in order to emit the first photon and the second photon.

7. The method of claim 1, further comprising the step of the imaging software module estimating the density of the target based on data collected by the gamma detector and the imaging detector.

8. A system for creating an image of a target, the system comprising:

a radioisotope source that generates a positron that collides with an electron and emits a first photon and a second photon;

a photon tagger measuring a first trajectory and a first time associated with the first photon;

an imaging software module installed on a computer, the imaging software module receiving the first time and the first trajectory associated with the first photon and calculating a second trajectory and a second time associated with the second photon;

a target that interacts with the second photon and emits a scattered photon;

a detector measuring a scattered trajectory and a scattered time associated with the scattered photon, wherein the imaging software module calculates a position of the target using the scattered trajectory and the scattered time associated with the scattered photon and the second trajectory and the second time associated with the second photon.

9. The system of claim 8, wherein the detector comprises shielding to reduce the number of background photons that reach the detector.

10. The system of claim 8, wherein the detector is a coded aperture imager comprising an array of detectors and a patterned mask.

11. The system of claim 8, wherein the radioisotope source and the detector are located on one side of the target such that the angle between the second trajectory of the second photon and the scattered trajectory of the scattered photon is less than 180 degrees.

12. The system of claim 8, wherein the imaging software module filters a second scattered photon based on a second scattered time associated with the second scattered photon.

13. The system of claim 8, wherein the imaging software module filters a second scattered photon based on a second energy level associated with the second scattered photon.

14. The system of claim 8, further comprising a source holder for containing the radioisotope source, wherein the source holder comprises a first window for emitting the first photon and a seconds window for emitting the second photon.

15. The system of claim 8, wherein the imaging software module estimates the density of the target based on the data collected from the photon tagger and the detector.

16. A computer program product comprising an imaging software module stored on a non-transitory computer-readable medium, the imaging software module comprising:

instructions for receiving a first trajectory and a first time from a gamma detector, the first trajectory and the first time associated with a first photon, the first photon being part of a photon pair generated from a collision between a positron and an electron;

instructions for calculating a second time and a second trajectory associated with a second photon, the second photon being part of the photon pair;

instructions for receiving a scattered trajectory and a scattered time from an imaging detector, the scattered trajectory and the scattered time associated with a scattered photon generated from a collision between the second photon and a target;

instructions for calculating a position within the target based on the second time, the second trajectory, the scattered time and the scattered trajectory.

17. The computer program product of claim 16, further comprising:

instructions for receiving a second scattered trajectory and a second scattered time from the imaging detector, the second scattered trajectory and the second scattered time associated with a second scattered photon; and

instructions for filtering the second scattered photon based on the second scattered time.

18. The computer program product of claim 16, further comprising:

instructions for receiving a second scattered trajectory and a second scattered energy level from the imaging detector, the second scattered trajectory and the second scattered energy level associated with a second scattered photon; and

instructions for filtering the second scattered photon based on the second scattered energy level.

19. The computer program product of claim 16, wherein the positron is emitted by a radioisotope source.

20. The computer program product of claim 16, further comprising:

instructions for estimating the density of the target based on the data collected from the scattered detector and the imaging detector.