Tissue sample identification system and apparatus

• US 8,315,445 B2
• Filed: 05/15/2006
• Issued: 11/20/2012
• Est. Priority Date: 05/13/2005
• Status: Active Grant

• Current Assignee: Vision Biosystems Incorporated (Vision Box - Soluções de Visão Por Computador SA)
• Original Assignee: Leica Biosystems Melbourne Pty. Ltd. (Danaher Corporation)
• Inventors: Sorenson, Paul, Zawadzki, Chris
• Primary Examiner(s): Hollington, Jermele M
• Assistant Examiner(s): CHAN, EMILY Y
• Application Number:
  US11/914,369
• Publication Number:
  US 20090214088A1
• Time in Patent Office: 2,381 Days
• Field of Search: 382128-133, 382/306, 600407-464, 702/19
• US Class Current: 382/128
• CPC Class Codes: G01N 1/312 for samples mounted on planar substrates
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers

Abstract

A method an apparatus for identifying slides is disclosed, where samples such as tissue sample mounted to slides are labeled with information, and an image of the information is captured by a processing instrument. The image is analyzed, for example using optical character recognition, and information extracted from the image is used to determine the test to be applied to the slide by the processing instrument. Where information about the slide cannot be extracted from the image, the image is presented to a user to that the slide information, such as its identity or the test to be applied, may be selected by the user to allow the slide to be processed.

Claims

1. A method of sample identification, the method comprising:

capturing an image of at least part of a sample support;

processing the image to determine whether identification information in the image is identified as matching with processing information;

when the identification information is not identified, displaying said image on a screen for identification by a user; and

presenting the user with a list of identifiers representing identification information of sample supports when the identification information is not identified.

2. The method of claim 1, further comprising associating processing steps with the image using information extracted from the image.

3. The method of claim 1 further comprising allowing the user to match the image of the sample support not identified with one of the identifiers to manually identify the sample.

4. The method of claim 1 wherein the list of identifiers includes those identifiers from a pool of identifiers that have been entered into a database, but which have not already been associated with a sample support.

5. The method of claim 1 further comprising when identification information within the image is automatically identified, associating the sample with processing information.

6. A method of automatically identifying sample holders, the method comprising:

capturing an image of a label on a sample holder and analyzing the image to extract information from the image;

when information is extracted, associating the information with the sample holder and determining a protocol or test to be applied to a sample on the sample holder based on the information extracted from the image;

analysing the image and extracting information;

comparing the extracted information to identifiers in a database;

determining the protocol or test to be applied to the sample based on the identifiers of the database; and

when information cannot be extracted from the image;

ascertaining the protocol or test to be applied to the sample on the sample holder by displaying the captured image to a user, allowing the user to select from a group of tasks not yet assigned to any other sample holders, wherein selecting a task determines the test or protocol to be applied to the sample holder.

7. A method of identifying tissue samples on slides, the method comprising:

capturing an image containing information from a slide,

assigning the image containing the slide information a unique identifier,

ascertaining whether the captured slide information is sufficient to initiate a process on the slide,

requesting additional information required to complete the slide when the captures slide information is insufficient, and

assigning a test protocol to the slide based on the information from the image and additional information.

8. The method of claim 7 further comprising ascertaining whether the captured slide information is sufficient to initiate a process on the slide comprises analysing the image to extract the slide information.

9. An apparatus for processing samples comprising:

an imager that captures an image of at least a portion of a sample support containing a sample;

a display that displays the image;

a processor that processes the image to determine whether identification information in the image is recognized and matches with processing information,

when the identification information is not identified, displaying the image on the display for identification by a user,

wherein in response to the image being determined to be not identified, information is displayed to the user that comprises a list of identifiers representing identification information of sample supports.

10. The apparatus of claim 9, wherein in response to the processor determining that the image is recognized, the processor associates processing steps to be performed on the sample.

11. The method of claim 9, wherein the list of identifiers includes those identifiers from a pool of identifiers that have been entered into a database, but which have not already been associated with a sample support.

12. A method for processing a sample on a slide using an automated tissue staining instrument having an imager for capturing identification information from a slide and a testing portion for testing the slide based on identification information, the method comprising:

loading a slide with a tissue sample disposed thereon into the automated tissue staining instrument, where identification information is on at least a portion of the slide;

capturing an image of the identification information to determine whether the identification information is identified as matching with processing information;

displaying the image on a display if the identification information is not identified and obtaining the identification information related thereto;

testing the sample on the slide based on the identification information, wherein the testing comprises at least applying a reagent to the slide.