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Method for noninvasive measurement of glucose and apparatus for noninvasive measurement of glucose

  • US 8,315,681 B2
  • Filed: 04/06/2009
  • Issued: 11/20/2012
  • Est. Priority Date: 11/30/2005
  • Status: Active Grant
First Claim
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1. A method comprising the steps of:

  • inducing a change in glucose metabolism in a nutrient capillary in skin by temperature-changed glycolysis;

    measuring a change in localized reflectance light signals at a plurality of light source-detector distances and a plurality of wavelengths over a specific time period after skin-probe contact as a function of a time for which a localized reflectance probe is brought into contact with the skin, said temperature-changed glycolysis causing a change with respect to light attenuation, oxygen consumption in a tissue and concentration of a hemoglobin variant;

    selecting a time window in which a tissue-probe adaptation effect on the signals is minimized and an effect on glycolysis induced by temperature has time dependence, and using a signal measured in the time window for a subsequent calculation;

    calculating one set of functions based on a plurality of localized reflectance values at the plurality of light source-detector distances and the plurality of wavelengths at a plurality of time intervals in the time window and at least two wavelengths;

    deriving a calibration relationship between a combination of the calculated functions and a glucose concentration in a living body; and

    using the calibration relationship for predicting a glucose concentration in a body fluid in subsequent measurement,wherein at least one function in the plurality of time intervals is associated with a change in oxygen consumption.

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