Cortical electrode array and method for stimulating and recording brain activity

• US 8,315,686 B2
• Filed: 01/30/2009
• Issued: 11/20/2012
• Est. Priority Date: 01/30/2008
• Status: Active Grant

• Current Assignee: New York University
• Original Assignee: New York University
• Inventors: Llinas, Rodolfo R., Sugimori, Mutsuyuki
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): ALTER, ALYSSA MARGO
• Application Number:
  US12/362,805
• Publication Number:
  US 20090192569A1
• Time in Patent Office: 1,390 Days
• Field of Search: 607/36, 607/45, 607/155, 607/115, 607/116, 600/378, 600/544
• US Class Current: 600/378
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole

Abstract

An electrode device and a method of installing the electrode device in the vicinity of the brain. The electrode device includes a plurality of electrode assemblies, each with at least one electrode lead, extending from a common base. The base is configured to be positioned on an outside of the patient'"'"'s cranium with each electrode assembly projecting individually through a hole in the patient'"'"'s cranium such that the electrode lead is in the vicinity of the brain. The method of installation includes carving a recess out of the patient'"'"'s cranium and inserting the base therein. Each of the electrode assemblies are placed in their respective holes in order to stimulate, monitor or record neurological activity. The electrode device may be used over long periods of time for chronic treatment or recording.

Claims

1. An electrode array assembly for providing electrical communication with tissue including dura mater which is within a cranium having a thickness, a recess therein, a layer of the cranium, a plurality of through holes in the cranium and an outer lamella layer of the cranium, the assembly comprising:

a base having an outer surface and having a structure enabling the base to be received in the recess formed in the cranium, the recess having a shape which is complementary to the base and a depth for the base which is less than the thickness of the cranium such that the layer of the cranium is provided between the base and the tissue and the outer surface of the base having a smooth transition with the outer lamella layer exposed to an environment outside the cranium;

a plurality of electrode assemblies mounted directly underneath and to the base, each electrode assembly mounted at a respective first end to the base and extending in a generally outward direction away from the base toward a respective second end, each individual one of the electrode assemblies having a structure to be received within a respective one of the plurality of through holes in the layer of the cranium provided between the base and the tissue, thereby providing a substantial fit for each of the electrode assemblies to the respective one of the plurality of through holes and each electrode assembly including a conductive element for providing electrical communication between a respective portion of the tissue and a respective electrical conductor associated with the base and corresponding to the respective electrode assembly.

2. The electrode array assembly of claim 1, wherein the plurality of electrode assemblies are disposed in an array including a plurality of rows and a plurality of columns.

3. The electrode array assembly of claim 1, wherein the second end of the at least one of the plurality of electrode assemblies is configured to rest in a vicinity of the dura mater of the patient.

4. The electrode array assembly of claim 1, wherein at least one of the plurality of electrode assemblies is configured to penetrate into the brain tissue.

5. The electrode array assembly of claim 1, wherein at least one of the plurality of electrode assemblies includes a stimulating electrode lead.

6. The electrode array assembly of claim 1, wherein at least one of the electrode assemblies includes a monitoring electrode lead.

7. The electrode array assembly of claim 1, where at least one of the plurality of electrode assemblies includes more than one electrode lead.

8. The electrode array assembly of claim 1 further comprising a recording system configured to record electrical communication monitored by at least one of the plurality of electrode assemblies.

9. The electrode array assembly of claim 1 further comprising a communications interface connected to the plurality of electrode assemblies and configured to communicate at least one of electrical communications monitored by the electrode assemblies and stimulating activity to be carried out by the electrode assemblies.

10. The electrode array assembly of claim 9 for use in a chest of a patient wherein the communications interface is disposed in a housing, the housing configured to receive a power source and configured to be disposed in the chest of the patient.

11. The electrode array assembly as defined in claim 1 wherein an outer surface of the base is substantially flush with an outer surface of the patient'"'"'s cranium.

12. A method of treating a patient with an electrode array assembly for providing electrical communication with tissue including dura mater inside the patient'"'"'s cranium having a recess with a plurality of through holes and an outer lamella layer, the method comprising:

providing an electrode array assembly including a base with an outer surface and a plurality of electrode assemblies mounted directly underneath and to the base, each electrode assembly having a first end adjacent the base and extending in a generally outward direction away from underneath the base to a respective second end, and each electrode assembly including a conductive element;

forming a recess in an outer surface of the patient'"'"'s cranium, the recess having a shape complementary to the base and a depth which is less than a thickness of the cranium such that a recessed portion of the cranium is provided within the recess and the outer surface of the base having a smooth transition with the outer lamella layer of the patient'"'"'s cranium exposed to an environment outside the cranium;

boring a plurality of the through holes through the recess of the cranium;

inserting the base into the recess;

disposing each electrode assembly in a respective one of the plurality of the through holes in the recess of the cranium such that the second end of each electrode assembly is disposed in a vicinity of a respective portion of the tissue and each electrode of the electrode assembly having a substantial fit and complementary shape for the respective one of the plurality of through holes which receives each of the electrodes; and

conducting electrical communication between the conductive element of each electrode assembly and the tissue.

13. The method of claim 12, wherein the second end of at least one of the plurality of electrode assemblies penetrates the brain tissue and the respective portion of the tissue includes the brain tissue.

14. The method of claim 12, wherein the electrical communication includes monitoring activity of the patient'"'"'s brain.

15. The method of claim 14, further comprising providing a recording system in communication with the electrode array assembly, and

recording the monitored activity of the patient'"'"'s brain.

16. The method of claim 12 wherein the electrical communication includes stimulating the patient'"'"'s brain.

17. The method of claim 12, further comprising providing a communications interface in communication with each conductive element, and

providing communications between the electrode array assembly and an external electronic device through the communications interface.

18. The method of claim 12 wherein the recess is formed in the outer lamella of the patient'"'"'s cranium.

19. The method of claim 12 further comprising fixing the base of the electrode array assembly in the recess.

20. The method of claim 12 wherein an outer surface of the base is substantially flush with an outer surface of the patient'"'"'s cranium.