Pumping cassette

• US 8,317,492 B2
• Filed: 10/12/2007
• Issued: 11/27/2012
• Est. Priority Date: 02/27/2007
• Status: Active Grant

• Current Assignee: Deka Products Limited Partnership
• Original Assignee: Deka Products Limited Partnership
• Inventors: Demers, Jason A., Wilt, Michael J., Grant, Kevin L., Dale, James D., Tracey, Brian
• Primary Examiner(s): Kramer, Devon
• Assistant Examiner(s): LETTMAN, BRYAN MATTHEW
• Application Number:
  US11/871,712
• Publication Number:
  US 20090004033A1
• Time in Patent Office: 1,873 Days
• Field of Search: 417/232, 417/379, 417/413.1, 417/439, 417/442, 417/323, 417/392, 417/394, 417/395, 417/440, 417/521, 210/645, 210/646, 604/6.11
• US Class Current: 417/395
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1639 linked by membranes
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1664 with temperature control
• CPC Class Codes: A61M 1/1666 by dissolving solids
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/268 the displacement member being flexible, e.g. membranes, diaphragms or bladders
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/427 : the force acting on the blood contacting member being hydraulic or pneumatic
• CPC Class Codes: A61M 60/43 : using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/837 : Aspects of flexible displacement members, e.g. shapes or materials
• CPC Class Codes: A61M 60/847 : arranged in a cassette
• CPC Class Codes: A61M 60/849 : Disposable parts
• CPC Class Codes: A61M 60/851 : Valves
• CPC Class Codes: A61M 60/892 : Active valves, i.e. actuated by an external force
• CPC Class Codes: A61M 60/894 : Passive valves, i.e. valves actuated by the blood
• CPC Class Codes: F04B 13/02 : of two or more fluids at the same time
• CPC Class Codes: F04B 23/06 : the pumps being all of reciprocating positive-displacement type
• CPC Class Codes: F04B 41/06 : Combinations of two or more pumps
• CPC Class Codes: F04B 43/00 : Machines, pumps, or pumping installations having flexible working members pumps or pumping installations specially adapted for elastic fluids F04B45/00
• CPC Class Codes: F04B 43/026 : each plate-like pumping flexible member working in its own pumping chamber
• CPC Class Codes: F04B 43/06 : Pumps having fluid drive
• CPC Class Codes: F04B 43/0736 : with two or more pumping chambers in parallel
• CPC Class Codes: F04B 45/02 : having bellows
• CPC Class Codes: F04B 45/0536 : the actuating fluid being controlled by one or more valves
• CPC Class Codes: F04B 49/02 : Stopping, starting, unloading or idling control
• CPC Class Codes: F04B 49/22 : by means of valves F04B49/03 takes precedence
• CPC Class Codes: F04B 53/06 : Venting
• CPC Class Codes: F04B 53/10 : Valves; Arrangement of valves
• CPC Class Codes: F04B 53/16 : Casings; Cylinders; Cylinder liners or heads; Fluid connections
• CPC Class Codes: F04B 7/02 : the valving being fluid-actuated
• CPC Class Codes: F04B 9/109 : having plural pumping chambers
• CPC Class Codes: F17D 3/00 : Arrangements for supervising or controlling working operations
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 137/0324 : With control of flow by a condition or characteristic of a fluid
• CPC Class Codes: Y10T 137/0379 : By fluid pressure
• CPC Class Codes: Y10T 137/2521 : Flow comparison or differential response
• CPC Class Codes: Y10T 137/85978 : With pump
• CPC Class Codes: Y10T 137/86139 : Serial

Abstract

A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.

Claims

1. A disposable cassette configured for operative association with a base unit to replace a volume of a first liquid with a substantially equal volume of a second liquid, the disposable cassette comprising:

the first fluid flow network for the first liquid and the second fluid flow network for the second liquid, the first fluid flow network comprising an inlet port and an outlet port for the first liquid, and the second fluid flow network comprising an inlet port and an outlet port for the second liquid;

a first balancing pod and a second balancing pod, each balancing pod separated into a first chamber and a second chamber by a flexible membrane configured to provide a seal between the first chamber and the second chamber, wherein the first chamber is in fluid communication with the first fluid flow network and the second chamber is in fluid communication with the second fluid flow network;

the first chamber of each of the first and second balancing pods having at least one first chamber balancing pod port for ingress and/or egress of the first liquid, each at least one first chamber balancing pod port in fluid communication with a valve to permit a fluid flow between the first chamber and the inlet port of the first fluid flow network, and in fluid communication with a valve to permit a fluid flow between the first chamber and the outlet port of the first fluid flow network, and;

the second chamber of each of the first and second balancing pods having at least one second chamber balancing pod port for ingress and/or egress of the second liquid, each at least one second chamber balancing pod port in fluid communication with a valve to permit a fluid flow between the second chamber and the inlet port of the second fluid flow network, and in fluid communication with a valve to permit a fluid flow between the second chamber and the outlet port of the second fluid flow network; and

a first reciprocating positive displacement membrane pump and a second reciprocating positive displacement membrane pump both in fluid communication with the second fluid flow network,

the first reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the second fluid flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the first balancing pod;

the second reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the second fluid flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the second balancing pod;

wherein the disposable cassette can be operated by the base unit so that

a first volume of the second liquid can be drawn through the inlet port of the second fluid flow network by the first reciprocating positive displacement membrane pump, stored in the first reciprocating positive displacement membrane pump, and pumped to the second chamber of the first balancing pod to displace the flexible membrane of the first balancing pod and move a first volume of the first liquid out of the first chamber of the first balancing pod to exit the cassette through the outlet port of the first fluid flow network, and

a second volume of the second liquid can be drawn through the inlet port of the second fluid flow network by the second reciprocating positive displacement membrane pump, stored in the second reciprocating positive displacement membrane pump, and pumped to the second chamber of the second balancing pod to displace the flexible membrane of the second balancing pod and move a second volume of the first liquid out of the first chamber of the second balancing pod to exit the cassette through the outlet port of the first fluid flow network.

2. The disposable cassette of claim 1, wherein the first and second reciprocating positive displacement membrane pumps and each of the valves has a fluidic control port through which a fluid under a positive or a negative pressure can actuate each pump and each of the valves to permit directed movement of the first and the second liquids within the cassette.

3. The disposable cassette of claim 1, wherein the valves are pneumatically actuated fluid valves, and the cassette comprises a top plate, a middle plate and a bottom plate, the top plate defining the first fluid flow network for the first liquid and the second fluid flow network for the second liquid;

the middle plate providing support for at least one flexible membrane; and

the bottom plate defining control chambers and fluidic control ports configured and positioned to operate the valves and the pumps.

4. The disposable cassette of claim 1, further comprising a metering pump, the metering pump comprising a metering pump inlet port in fluid communication through a metering inlet valve with the inlet port of the second fluid flow network, and a metering pump outlet port in fluid communication through a metering outlet valve with the outlet port of the second fluid flow network.

5. The disposable cassette of claim 4, wherein the metering pump is a reciprocating positive displacement membrane pump having an actuation chamber and a fluidic control port through which a fluid under a positive or a negative pressure can actuate the metering pump.

6. The disposable cassette of claim 5, wherein the metering pump is actuated by a pneumatic pressure or a vacuum, and the metering inlet valve and the metering outlet valve of said metering pump are pneumatically actuated fluid valves.

7. The disposable cassette of claim 1, wherein the at least one first chamber balancing pod port comprises a single port configured for both ingress and egress of the first liquid.

8. The disposable cassette of claim 1, wherein the at least one second chamber balancing pod port comprises a single port configured for both ingress and egress of the second liquid.

9. A disposable cassette configured for operative association with a base unit of a dialysis apparatus to replace a volume of a spent dialysate from a dialyzer with a substantially equal volume of a fresh dialysate, the disposable cassette comprising:

a fresh dialysate flow network and a spent dialysate flow network, the fresh dialysate flow network comprising an inlet port and an outlet port for the fresh dialysate, and the spent dialysate flow network comprising an inlet port and an outlet port for the spent dialysate;

a first balancing pod and a second balancing pod, each balancing pod separated into a first chamber and a second chamber by a flexible membrane configured to provide a seal between the first chamber and the second chamber, wherein the first chamber is in fluid communication with the fresh dialysate flow network and the second chamber is in fluid communication with the spent dialysate flow network;

the first chamber of each of the first and second balancing pods having at least one first chamber balancing pod port for ingress and/or egress of the fresh dialysate, each at least one first chamber balancing pod port in fluid communication with a valve to permit fluid flow between the first chamber and the inlet port of the fresh dialysate flow network, and in fluid communication with a valve to permit fluid flow between the first chamber and the outlet port of the fresh dialysate flow network, and;

the second chamber of each of the first and second balancing pods having at least one second chamber balancing pod port for ingress and/or egress of the spent dialysate, each at least one second chamber balancing pod port in fluid communication with a valve to permit fluid flow between the second chamber and the inlet port of the spent dialysate flow network, and in fluid communication with a valve to permit fluid flow between the second chamber and the outlet port of the spent dialysate flow network; and

a first reciprocating positive displacement membrane pump and a second reciprocating positive displacement membrane pump, both in fluid communication with the spent dialysate flow network,

the first reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the spent dialysate flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the first balancing pod;

the second reciprocating positive displacement membrane pump having a pump inlet in fluid communication through a valve with the inlet port of the spent dialysate flow network, and a pump outlet in fluid communication with the at least one second chamber balancing pod port of the second balancing pod;

wherein

the disposable cassette can be operated by the base unit so that

a first volume of the spent dialysate can be drawn through the inlet port of the spent dialysate flow network by the first reciprocating positive displacement membrane pump, stored in the first reciprocating positive displacement membrane pump, and pumped to the second chamber of the first balancing pod to displace the flexible membrane of the first balancing pod and move a first volume of fresh dialysate out of the first chamber of the first balancing pod to exit the cassette through the outlet port of the fresh dialysate flow network, and

a second volume of the spent dialysate can be drawn through the inlet port of the spent dialysate flow network by the second reciprocating positive displacement membrane pump, stored in the second reciprocating positive displacement membrane pump, and pumped to the secons chamber of the second balancing pod to displace the flexible membrane of the second balancing pod and move a second volume of fresh dialysate out of the first chamber of the second balancing pod to exit the cassette through the outlet port of the fresh dialysate flow network.

10. The disposable cassette of claim 9, further comprising an ultrafiltration metering pump, a metering inlet port of said ultrafiltration metering pump being in fluid communication through a valve with the inlet port of the spent dialysate flow network, and a metering outlet port of said ultrafiltration metering pump being in fluid communication through a valve with the outlet port of the spent dialysate flow network, wherein

at least a portion of fluid flow lines in fluid communication with the ultrafiltration metering pump is separate from fluid lines of the cassette that communicate with the balancing pods, and

the ultrafiltration metering pump can be operated to bypass the balancing pods so that a pre-determined amount of the spent dialysate can be pumped from a dialyzer in fluid communication with the inlet port of the spent dialysate flow network through the cassette and to the outlet port of the spent dialysate flow network without being replaced by an equal amount of fresh dialysate.

11. The disposable cassette of claim 9, wherein the at least one first chamber balancing pod port comprises a single port configured for both ingress and egress of the fresh dialysate.

12. The disposable cassette of claim 9, wherein the at least one second chamber balancing pod port comprises a single port configured for both ingress and egress of the spent dialysate.