Flow balancing and synchronization system and method, especially for citrate

• US 8,317,750 B2
• Filed: 04/20/2010
• Issued: 11/27/2012
• Est. Priority Date: 10/15/2003
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Ware, Lee C., Boehnlein, Arnold F.
• Primary Examiner(s): Mendez, Manuel
• Application Number:
  US12/763,864
• Publication Number:
  US 20100200506A1
• Time in Patent Office: 952 Days
• Field of Search: 604/6.07, 604 401- 10, 604/131, 604 65- 67, 604/890.1, 128/DIG.12, 128/DIG.13
• US Class Current: 604/131
• CPC Class Codes: A61M 1/3434 with pre-dilution and post-dilution
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3441 Substitution rate control as a function of the ultrafiltration rate
• CPC Class Codes: A61M 1/3451 the difference in weight between both ultra-filtrate and substitution reservoir being used as control signal
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

A renal failure therapy system includes a blood pump; a citrate pump; and a control unit configured to automatically control the blood pump and the citrate pump to achieve a citrate flowrate that is based on a blood flowrate, so that the flowrates are synchronized.

Claims

1. A renal failure therapy system comprising:

a blood pump;

a citrate pump;

a filtrate pump; and

a control unit configured to automatically control the blood pump, the citrate pump, and the filtrate pump to (i) achieve a citrate flowrate that is based on a blood flow rate so the flowrates are synchronized, (ii) perform the equation;

filtrate pump rate=total input rate−

total output rate+prescribed net loss rate, and (iii) control the filtrate pump according to the calculated filtrate pump rate.

2. The renal failure therapy system of claim 1, which includes a sensor, and wherein the control unit is configured to determine the at least one of the total input rate and the total output rate by receiving at least one input/output flowrate that has been sensed by the sensor.

3. The renal failure therapy system of claim 1, which includes an input device operable with the control unit, and wherein the control unit is configured to determine the at least one of the total input rate and the total output rate by receiving at least one input/output flowrate that has been inputted manually into the input device.

4. A renal failure therapy method comprising:

pumping blood through a blood circuit of a renal failure therapy machine;

infusing citrate as an anticoagulant;

configuring the renal failure therapy machine to perform the equation;

a filtrate pump rate=a total input rate−

a total output rate+a prescribed net loss rate, wherein the total input rate includes the flowrate of citrate; and

controlling (i) a flowrate of the citrate based on a flowrate of the blood automatically so that the flowrates are synchronized, and (ii) a filtrate pump according to the calculated filtrate pump rate.

5. The method of claim 4, wherein determining at least one of the total input rate and the total output rate includes receiving at least one input/output flowrate that has been sensed by a sensor.

6. The method of claim 4, wherein determining at least one of the total input rate and the total output rate includes receiving at least one input/output flowrate that has been inputted manually.

7. The method of claim 4, wherein determining the total input rate includes summing a plurality of drug flowrates, including citrate, delivered to the blood circuit.