Apparatus and methods for the controllable modification of compound concentration in a tube

• US 8,317,760 B2
• Filed: 10/31/2007
• Issued: 11/27/2012
• Est. Priority Date: 10/22/1999
• Status: Expired due to Term

• Current Assignee: Biosynergetics, Inc.
• Original Assignee: Biosynergetics, Inc.
• Inventors: Nyhart, Eldon H.
• Primary Examiner(s): Shumate, Victoria P
• Application Number:
  US11/931,729
• Publication Number:
  US 20090118696A1
• Time in Patent Office: 1,854 Days
• Field of Search: 604/28, 604/31, 604 65- 67, 604264-266, 604503-505, 604/532, 604/890.1, 604/891.1
• US Class Current: 604/265
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61M 39/08 Tubes; Storage means specially adapted therefor
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances

Abstract

Methods for delivery of a compound within a tube.

Claims

1. A method for providing a compound into a flowing fluid, comprising:

providing a section of tubing;

providing a matrix material bonded to an interior of the tubing; and

providing a compound captured in the matrix material;

the compound being releasable from the matrix material upon application of irradiation of the matrix material by a laser, wherein said irradiation is in a fractally-based pattern.

2. The method of claim 1, wherein the step of providing a compound captured in the matrix includes photolabily bonding the molecules of the compound to molecules of the matrix.

3. The method of claim 2, wherein the matrix material reacts to the application of energy by breaking the photolabile bonds.

4. The method of claim 1, wherein the matrix material is a hydrogel.

5. The method of claim 1, wherein the compound is an anticoagulant.

6. The method of claim 1, wherein the step of providing a compound captured in the matrix includes bonding the compound to the matrix material.

7. The method of claim 6, wherein the bonding is covalent bonding.

8. The method of claim 1, further comprising the step of forming a lumen within the matrix material suitable for flowing a fluid therethrough.

9. The method of claim 1, wherein the matrix material is inert.