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Super fast-acting insulin compositions

  • US 8,318,154 B2
  • Filed: 04/28/2009
  • Issued: 11/27/2012
  • Est. Priority Date: 04/28/2008
  • Status: Expired due to Fees
First Claim
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1. A super fast-acting insulin composition, comprising:

  • a therapeutically effective amount of a fast-acting insulin analog for controlling blood glucose levels, wherein the fast-acting analog is insulin aspart or insulin glulisine; and

    an amount of a hyaluronan degrading enzyme sufficient to render the composition a super fast-acting insulin composition, wherein;

    the sufficient amount of a hyaluronan degrading enzyme to render the composition a super fast-acting insulin composition is 1 Unit or more hyaluronidase activity/mL;

    the super fast-acting insulin composition has an onset of action that is shorter than the analog alone, and a duration of action that is shorter than the analog alone, whereby, upon administration, the composition closely mimics the physiologic post-prandial insulin response of a non-diabetic subject to achieve glycemic control; and

    the super fast-acting insulin composition is formulated for a route of administration selected from among subcutaneous, intradermal and intraperitoneal administration.

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