Dietary supplements containing extracts of cinnamon and methods of using same to enhance creatine transport

• US 8,318,221 B2
• Filed: 07/21/2011
• Issued: 11/27/2012
• Est. Priority Date: 04/11/2003
• Status: Active Grant

• Current Assignee: IN Ingredients, Inc.
• Original Assignee: F.H.G. Corporation
• Inventors: Miller, Peter J., Romero, Timothy
• Primary Examiner(s): TATE, CHRISTOPHER ROBIN
• Application Number:
  US13/187,771
• Publication Number:
  US 20110280973A1
• Time in Patent Office: 495 Days
• Field of Search: None
• US Class Current: 424/739
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/33 High-energy foods and drinks, sports drinks
• CPC Class Codes: A23V 2200/332 Promoters of weight control and weight loss
• CPC Class Codes: A23V 2250/161 Magnesium
• CPC Class Codes: A23V 2250/21 Plant extracts
• CPC Class Codes: A23V 2250/306 Creatine
• CPC Class Codes: A23V 2250/5114 Dextrins, maltodextrins
• CPC Class Codes: A23V 2250/616 Maltose
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 36/54 Lauraceae (Laurel family), e.g. cinnamon or sassafras
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

Materials derived from cinnamon can be administered orally to humans or animals for the purpose of controlling blood glucose as well improving glucose tolerance. Controlling glucose metabolism is essential for those with impaired glucose metabolism as is the case for those with Type II diabetes where insulin function is not properly functioning. Such administration can also be used for the purpose of enhancing nutrient transport for purposes of athletic performance and controlling bodyweight and body fat levels. Similarly related, such administration can also be used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material can be administered as extracts of cinnamon and can be administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.

Claims

1. A dietary supplement consisting essentially of:

a. a first ingredient consisting of;

a water-soluble extract of cinnamon;

b. a second ingredient consisting essentially of;

arginine, glycine, or methionine; and

c. optionally, at least one carbohydrate;

wherein said water-soluble extract of cinnamon functions synergistically with said second ingredient at a daily intake of between 10 and 2,000 milligrams of said water-soluble extract of cinnamon and between 100 and 25,000 milligrams of said second ingredient to increase the uptake of creatine by a muscle of a subject by an insulin dependent pathway and said water-soluble extract of cinnamon decreases glucose intolerance.

2. The dietary supplement of claim 1, wherein the carbohydrate is selected from the group consisting of dextrose, maltose, maltodextrin and trehalose.

3. The dietary supplement of claim 1 wherein element (a) is present in an amount from about 0.1 mg to about 100 mg per gram of dietary supplement and element (b) is present in an amount from about 10 mg to about 900 mg per gram of dietary supplement and the dietary supplement lacks said at least one carbohydrate.

4. The dietary supplement of claim 1 or 3 wherein said at least one carbohydrate is present in an amount of from about 1 mg to about 950 mg per gram of dietary supplement.

5. The dietary supplement of claim 1, wherein said water-soluble extract of cinnamon is further characterized in that it is comprised of a fraction of cinnamon which is soluble in 0.1 N acetic acid.

6. The dietary supplement of claim 1, wherein element (a) is present in the amount of 2 mg per gram of the dietary supplement and element (b) is present in an amount of 104 mg per gram of the dietary supplement and the at least one carbohydrate is present.

7. The dietary supplement of claim 1 further comprising:

one or more of a creatine hydrates, creatine salts, glycocyamine, or guanidine acetic acid.

8. The dietary supplement of claim 7 wherein said dietary supplement comprises creatine monohydrate as said creatine hydrate and a creatine ester as said creatine salt.

9. A method of increasing total creatine content of skeletal muscle of a subject comprising:

administering for at least 4 days, within 60 minutes prior to a workout, the dietary supplement of claim 1 to the subject.

10. The method of claim 9 wherein said water-soluble extract is a fraction soluble in 0.1 N acetic acid.

11. The method of claim 9 wherein the total creatine content increases between 10% and 40%.

12. The method of claim 9 wherein said dietary supplement further comprises one or more of a creatine hydrates, creatine salts, glycocyamine, or guanidine acetic acid.

13. The method of claim 12 wherein said dietary supplement comprises creatine monohydrate as said creatine hydrate and a creatine ester as said creatine salt.

14. The method of claim 9 wherein said carbohydrate comprises maltodextrin.

15. The method of claim 9 further comprising administering said dietary supplement subsequent to the workout.

16. The method of claim 15 further comprising administering said dietary supplement on days intermediate between said workout and a subsequent workout.