Modulation of nitric oxide synthases by betaines
First Claim
1. A method for treating a patient suffering from a condition related to constitutive nitric oxide deficiency, wherein said condition is pulmonary hypertension, said method comprising the step of administering to the patient an efficient therapeutical amount of betaine for increasing in said patient at least one nitric oxide production pathway selected from the group consisting of constitutive nitric oxide synthase expression, constitutive Endothelial nitric oxide synthase expression, eNOS nitric oxide synthase expression, neural NOS nitric oxide synthase expression (nNOS), platelet NOS nitric oxide synthase expression, cNOS nitric oxide synthase expression, Type III nitric oxide synthase expressions, calcium dependant nitric oxide synthase expression, calcium dependant nitric oxide synthase production, endogenous nitric oxide production, and combinations thereof, said betaine being administered orally in an oral composition comprising at least (a) 20% by weight betaine and (b) 20% by weight L-arginine or a physiologically acceptable salt thereof.
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Abstract
The present invention relates to therapeutic compositions of betaines and L-arginine and physiologically acceptable salts thereof, and to pharmaceutical uses of betaines for up-regulating, enhancing, stimulating, controlling and/or increasing constitutive nitric oxide synthase expression a mammal, particularly in a human. Additionally, the betaines are believed to augment after administration both immunological and functional (activity) expression of Tissue Factor Pathway Inhibitor (TFPI) in a mammal, particularly a human.
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Citations
22 Claims
- 1. A method for treating a patient suffering from a condition related to constitutive nitric oxide deficiency, wherein said condition is pulmonary hypertension, said method comprising the step of administering to the patient an efficient therapeutical amount of betaine for increasing in said patient at least one nitric oxide production pathway selected from the group consisting of constitutive nitric oxide synthase expression, constitutive Endothelial nitric oxide synthase expression, eNOS nitric oxide synthase expression, neural NOS nitric oxide synthase expression (nNOS), platelet NOS nitric oxide synthase expression, cNOS nitric oxide synthase expression, Type III nitric oxide synthase expressions, calcium dependant nitric oxide synthase expression, calcium dependant nitric oxide synthase production, endogenous nitric oxide production, and combinations thereof, said betaine being administered orally in an oral composition comprising at least (a) 20% by weight betaine and (b) 20% by weight L-arginine or a physiologically acceptable salt thereof.
- 12. A method for treating a patient suffering from a condition related to excess endothelin-1 (ET-1), in which the patient is administered with an efficient therapeutical amount of betaine for lowering endothelin-1 (ET-1) levels in said patient, wherein said condition is pulmonary hypertension.
- 17. A method for treating a patient suffering from a condition related to endothelial cells, in which said patient is administered an efficient therapeutical amount of betaine for improving endothelial cell function through activation of eNOS and through protection of the endothelium from oxidative stress, wherein said condition is pulmonary hypertension.
- 19. A method for treating a patient suffering from a condition related to lack of activated eNOS, in which said patient is administered an efficient therapeutical amount of betaine to destabilize the complex between eNOS and caveolin for activating eNOS, wherein said condition is pulmonary hypertension.
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21. A method for increasing constitutive Nitric Oxide Synthase activity in a subject to treat a condition favorably affected by an increase in constitutive Nitric Oxide levels in a cell, a tissue, an organ, a bodily fluid, blood, comprising:
- administering to a subject in need of such treatment an effective amount of a betaine; and
co-administering a substrate of Nitric Oxide Synthase, wherein said condition is pulmonary hypertension. - View Dependent Claims (22)
- administering to a subject in need of such treatment an effective amount of a betaine; and
Specification