N-acyl amino acid derivatives, a method for the preparation thereof, a pharmaceutical composition and use thereof as anti-allergic, anti-inflammatory and hypolipidemic agents

• US 8,318,950 B2
• Filed: 04/21/2010
• Issued: 11/27/2012
• Est. Priority Date: 06/15/2005
• Status: Expired due to Fees

• Current Assignee: Aktsionernoe Obschestvo "Otechestvennye Lekarstva", Vladimir Evgenievich Nebolsin
• Original Assignee: Otkrytoe Aktsionernoe Obschestvo-Otechestvennye Lekarstva
• Inventors: Nebolsin, Vladimir Evgenievich, Kromova, Tatyana Alexandrovna, Kovaleva, Violetta Leonidovna, Zheltukhina, Galina Alexandrovna Alexandrovna
• Primary Examiner(s): Young, Shawquia
• Application Number:
  US12/764,515
• Publication Number:
  US 20100267962A1
• Time in Patent Office: 951 Days
• Field of Search: 548/338.1, 548/507
• US Class Current: 548/338.1
• CPC Class Codes: A61P 1/18 for pancreatic disorders, e.g. pancreatic enzymes
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 27/14 Decongestants or antiallergics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 209/20 substituted additionally by nitrogen atoms, e.g. tryptophane
• CPC Class Codes: C07D 233/64 with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Abstract

The present invention relates to N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof

• • wherein n is 2 or 3; and
  • R₁ represents

• • or pharmaceutically acceptable salts thereof, to novel processes for preparing the same, to use thereof as anti-allergic, anti-anaphylactic, anti-inflammatory and hypolipidemic agents as well as to a pharmaceutical composition comprising the indicated compounds in an efficient amount and to a method for treating allergic and inflammatory diseases and lipid metabolism disorders: bronchial asthma, allergic rhinitis, pollinoses, seasonal and year-round rhinitis, allergic pneumonitis, atopic dermatitis, psoriasis, urticaria, allergic (including anaphylactic) reactions to insect stings and medicaments, cold allergy, allergic conjunctivitis, atherosclerosis, obesity, ischemic heart and cerebral disease, myocardial infarction and stroke.

Claims

1. A process for preparing N-acyl derivatives of amino acids of general formula I

2. A process for preparing N-acyl derivatives of amino acids of general formula I

3. A process for preparing N-acyl derivatives of amino acids of general formula I