Electromechanical delay (EMD) monitoring devices, systems and methods

• US 8,321,017 B2
• Filed: 12/14/2009
• Issued: 11/27/2012
• Est. Priority Date: 07/08/2009
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Wenzel, Brian Jeffrey, Fayram, Timothy A., Keel, Allen J., Karst, Edward, Hou, Wenbo, Farazi, Taraneh Ghaffari
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): SARCIONE, JESSICA LYNN
• Application Number:
  US12/637,596
• Publication Number:
  US 20110040345A1
• Time in Patent Office: 1,079 Days
• Field of Search: 607/9, 607 17- 18, 607 25- 26, 607/28, 600/547
• US Class Current: 607/18
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 40/00 Manufacture or treatment of nanostructures
• CPC Class Codes: G03F 7/0002 Lithographic processes using patterning methods other than those involving the exposure to radiation, e.g. by stamping

Abstract

Implantable systems, and methods for use therewith, enable the monitoring of a patient'"'"'s electromechanical delay (EMD) and arterial blood pressure. Paced cardiac events are caused by delivering sufficient pacing stimulation to cause capture. A cardiogenic impedance (CI) signal, indicative of cardiac contractile activity in response to the pacing stimulation being delivered, is obtained. One or more predetermined features of the CI signal are detected, and a value indicative of the patient'"'"'s EMD is determined by determining a time between a delivered pacing stimulation and at least one of the detected one or more features of the CI signal. The value indicative of EMD can be used to more accurately determine metrics indicative of pulse arrival time (PAT), which can be used to estimate arterial blood pressure.

Claims

1. For use with an implantable system, a method for monitoring a patient'"'"'s electromechanical delay (EMD) and arterial blood pressure, the method comprising:

(a) causing paced cardiac events by delivering sufficient pacing stimulation to cause capture to the patient'"'"'s heart;

(b) using one or more electrodes implanted within and/or on the patient'"'"'s heart to obtain a cardiogenic impedance (CI) signal indicative of cardiac contractile activity while the patient'"'"'s heart is being paced at step (a);

(c) using an implanted sensor or implanted electrodes, remote from the patient'"'"'s heart, to obtain a plethysmography signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart while the patient'"'"'s heart is being paced at step (a);

(d) detecting one or more predetermined features of the CI signal obtained at step (b);

(e) detecting one or more predetermined features of the plethysmography signal obtained at step (c);

(f) determining a value indicative of the patient'"'"'s electromechanical delay (EMD) by determining a time between a pacing stimulation delivered at step (a) and at least one of the one or more predetermined features of the CI signal detected at step (d);

(g) determining a metric indicative of pulse arrival time (PAT) by determining a time between a pacing stimulation delivered at step (a) and at least one of the one or more predetermined features of the plethysmography signal detected at step (e), minus the determined value indicative of EMD; and

(h) estimating the patient'"'"'s arterial blood pressure based on the metric indicative of PAT determined at step (g);

wherein at least one of steps (f), (g) and (h) is/are performed using at least one processor.

2. The method of claim 1, further comprising:

(i) repeating steps (a)-(h) from time to time; and

(j) monitoring changes in the patient'"'"'s EMD and arterial blood pressure based on changes in the value indicative EMD determined at step (f) and changes in the estimates of arterial blood pressure determined at step (h).

3. The method of claim 2, further comprising:

(k) monitoring the patient'"'"'s heart failure (HF) condition based on changes in the patient'"'"'s EMD.

4. The method of claim 2, further comprising:

(k) adjusting pacing performed at step (a) to reduce variance of at least one of the one or more values indicative of the patient'"'"'s electromechanical delay (EMD).

5. The method of claim 1, wherein the one or more predetermined features of the CI signal detected at step (c) is/are selected from the group consisting of:

minimum amplitude of the CI signal;

maximum upward slope of the CI signal;

maximum amplitude of the CI signal; and

maximum downward slope of the CI signal.

6. An implantable system, comprising:

a pulse generator configured to generate pacing stimulation sufficient to cause capture, which can be delivered to a patient'"'"'s heart using at least one electrode implanted within or on the patient'"'"'s heart;

a cardiogenic impedance measurement circuit configured to obtain a cardiogenic impedance (CI) signal indicative of cardiac contractile activity;

an implantable sensor or electrodes configured to obtain a plethysmography signal indicative of changes in arterial blood volume remote from the patient'"'"'s heart while the patient'"'"'s heart is being paced using the pulse generator;

an electromechanical delay (EMD) monitor configured to

detect one or more predetermined features of a CI signal obtained using the CI measuring circuit while the patient'"'"'s heart is being paced using the pulse generator; and

determine a value indicative of the patient'"'"'s electromechanical delay (EMD) by determining a time between a pacing stimulation delivered to the patient'"'"'s heart and at least one of the one or more predetermined features of the CI signal;

an arterial pressure monitor configured to

detect one or more predetermined features of the plethysmography signal obtained by the implantable sensor or electrodes while the patient'"'"'s heart is being paced using the pulse generator;

determine a metric indicative of pulse arrival time (PAT) by determining a time between a pacing stimulation delivered to the patient'"'"'s heart and at least one of the one or more predetermined features of the plethysmography signal, minus the determined value indicative of EMD; and

estimate the patient'"'"'s arterial blood pressure based on the metric indicative of PAT.

7. The implantable system of claim 6, wherein the EMD monitor is also configured to monitor changes in the patient'"'"'s EMD over time based on changes over time in at least one of the one or more values indicative of EMD.

8. The implantable system of claim 7, further comprising:

a heart failure (HF) monitor configured to monitor the patient'"'"'s HF condition based on changes in the patient'"'"'s EMD.

9. The implantable system of claim 7, further comprising:

a controller configured to adjust pacing to reduce variance of at least one of the one or more values indicative of EMD.

10. The implantable system of claim 6, wherein the one or more predetermined features of the CI signal is/are selected from the group consisting of:

minimum amplitude of the CI signal;

maximum upward slope of the CI signal;

maximum amplitude of the CI signal; and

maximum downward slope of the CI signal.