Blood glucose measurement system

• US 8,323,195 B2
• Filed: 12/31/2008
• Issued: 12/04/2012
• Est. Priority Date: 12/31/2008
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Inventors: Ueda, Yasushi, Akizuki, Mamiko, Inoshita, Hiroyoshi
• Primary Examiner(s): WOOLWINE, SAMUEL C
• Application Number:
  US12/347,279
• Publication Number:
  US 20100168537A1
• Time in Patent Office: 1,434 Days
• Field of Search: None
• US Class Current: 600/365
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

A blood glucose measurement system in which a blood glucose level measured with an invasive blood glucose measurement apparatus 101 is used to calibrate a blood glucose level measured with a non-invasive blood glucose measurement apparatus 102, comprising a controller that outputs an invasive actuation signal that starts the detection of a characteristic quantity in the body with the invasive blood glucose measurement apparatus, and a blood sampling component for collecting blood from the body on the basis of the invasive actuation signal, wherein measurement with the invasive blood glucose measurement apparatus is begun when the amount of change in the estimated blood glucose level has reached or exceeded a non-invasive blood glucose threshold.

Claims

1. A blood glucose measurement system comprising:

an invasive blood glucose measurement apparatus; and

a non-invasive blood glucose measurement apparatus;

wherein the invasive blood glucose measurement apparatus includes;

a blood sampling component that collects blood from the body on the basis of an invasive measurement command from the non-invasive blood glucose measurement apparatus; and

a blood glucose level measurement component that measures a blood glucose level from blood collected by the blood sampling component,

wherein the non-invasive blood glucose measurement apparatus calibrates a measured blood glucose level by using a blood glucose level measured with the invasive blood glucose measurement apparatus,

wherein the non-invasive blood glucose measurement apparatus has;

a controller that outputs a non-invasive actuation signal that instructs the non-invasive blood glucose measurement apparatus to detect a characteristic quantity in the body, and an invasive actuation signal that instructs the invasive blood glucose measurement apparatus to begin measuring a blood glucose level;

a characteristic quantity detector that detects the characteristic quantity in the body on the basis of the non-invasive actuation signal;

a blood glucose level estimator that finds an estimated blood glucose level on the basis of the characteristic quantity detected by the characteristic quantity detector;

an invasive blood glucose information memory that stores blood glucose measurement information including a blood glucose level measured by the invasive blood glucose measurement apparatus;

a blood glucose level calibration calculator that calculates calibration data for calibrating the estimated blood glucose level on the basis of the blood glucose measurement information stored in the invasive blood glucose information memory and the estimated blood glucose level found by the blood glucose level estimator;

a blood glucose level calibrator that calibrates the estimated blood glucose level found by the blood glucose level estimator on the basis of the calibration data;

a non-invasive blood glucose level display component that displays the estimated blood glucose level calibrated by the blood glucose level calibrator; and

an invasive measurement command component that receives the invasive actuation signal outputted from the controller and instructs the invasive blood glucose measurement apparatus to measure the blood glucose level,

wherein the controller outputs the invasive actuation signal when the difference between the estimated blood glucose level and the blood glucose level measured by the invasive blood glucose measurement apparatus during calibration has reached or exceeded a preset non-invasive blood glucose threshold.

2. The blood glucose measurement system according to claim 1,

wherein the blood glucose level estimator comprises a register that can be written to from the outside, and the non-invasive blood glucose threshold can be changed according to the value of said register.

3. The blood glucose measurement system according to claim 1,

wherein the blood glucose level calibration calculator outputs a processing status signal indicating the conclusion of a calibration period when the amount of change in the blood glucose level measured by the invasive blood glucose measurement apparatus has reached or exceeded a preset invasive blood glucose threshold.

4. The blood glucose measurement system according to claim 3,

further comprising a register that can be written to from the outside, and the invasive blood glucose threshold can be changed according to the value of said register.

5. The blood glucose measurement system according to claim 1,

wherein the controller outputs the non-invasive actuation signal on the basis of a preset non-invasive measurement cycle.

6. The blood glucose measurement system according to claim 5,

wherein the controller comprises a register that can be written to from the outside, and the non-invasive measurement cycle can be changed according to the value of said register.

7. The blood glucose measurement system according to claim 1,

wherein the non-invasive blood glucose measurement apparatus comprises a processing status notification component that notifies the user with a processing status signal, and sends out a processing status signal that is outputted from the blood glucose level calibration calculator and indicates whether or not calibration is in progress.

8. The blood glucose measurement system according to claim 7,

wherein the processing status notification component notifies the user with sound.

9. The blood glucose measurement system according to claim 7,

wherein the processing status notification component notifies the user with light.

10. The blood glucose measurement system according to claim 7,

wherein the processing status notification component notifies the user with vibration.

11. The blood glucose measurement system according to claim 7,

wherein the processing status notification component notifies the user with a display.

12. The blood glucose measurement system according to claim 1,

wherein the invasive measurement command component instructs the user about the invasive blood glucose measurement apparatus with sound.

13. The blood glucose measurement system according to claim 1,

wherein the invasive measurement command component instructs the user about the invasive blood glucose measurement apparatus with light.

14. The blood glucose measurement system according to claim 1,

wherein the invasive measurement command component instructs the user about the invasive blood glucose measurement apparatus with vibration.

15. The blood glucose measurement system according to claim 1,

wherein the invasive measurement command component instructs the user about the invasive blood glucose measurement apparatus with a display.

16. The blood glucose measurement system according to claim 1,

wherein the blood glucose measurement information is the blood glucose levels measured with the blood glucose level measurement component and the timing at which these measurements were made.

17. The blood glucose measurement system according to claim 1,

wherein the blood glucose level estimator replaces the value of the non-invasive blood glucose threshold with the value of the invasive blood glucose threshold when the amount of change in a blood glucose level measured with the invasive blood glucose measurement apparatus from a time of 0 minutes has reached or exceeded the non-invasive blood glucose threshold.

18. The blood glucose measurement system according to claim 17,

wherein the blood glucose measurement information includes the blood glucose level measured with the blood glucose level measurement component, the timing at which these measurements were made, and the temperature at which these measurements were made.

19. The blood glucose measurement system according to claim 17,

wherein the blood glucose level estimator comprises a register that can be written to from the outside, and the function of replacing the non-invasive blood glucose threshold with the invasive blood glucose threshold can be switched on or off according to the value of said register.

20. The blood glucose measurement system according to claim 1,

wherein the invasive blood glucose measurement apparatus further has an invasive blood glucose level display component that displays the blood glucose level measured by the blood glucose level measurement component,

the invasive blood glucose level display component notifies the user of the blood glucose level measured by the blood glucose level measurement component, and

the blood glucose level calibration calculator calculates calibration data on the basis of the blood glucose level inputted by the user and the estimated blood glucose level found by the blood glucose level estimator.

21. The blood glucose measurement system according to claim 20,

wherein the invasive blood glucose level display component notifies the user with sound.

22. The blood glucose measurement system according to claim 20,

wherein the invasive blood glucose level display component notifies the user with light.

23. The blood glucose measurement system according to claim 20,

wherein the invasive blood glucose level display component notifies the user with vibration.

24. The blood glucose measurement system according to claim 20,

wherein the invasive blood glucose level display component notifies the user with a display.

25. The blood glucose measurement system according to claim 1,

wherein the invasive blood glucose measurement apparatus automatically begins measuring the blood glucose level according to a command from the invasive measurement command component of the non-invasive blood glucose measurement apparatus.

26. The blood glucose measurement system according to claim 1, wherein the controller outputs the invasive actuation signal when a specific length of time has elapsed since the blood glucose level was measured by the invasive blood glucose measurement apparatus even if the amount of change in the estimated blood glucose level has not reached or exceeded the preset non-invasive blood glucose threshold.

27. The blood glucose measurement system according to claim 26, wherein the controller comprises a register that can be written to from the outside, and the specific length of time can be changed according to the value of said register.

28. The blood glucose measurement system according to claim 1, wherein the controller outputs the invasive actuation signal when measurement has been repeated a specific number of times with the non-invasive blood glucose measurement apparatus since the blood glucose level was measured by the invasive blood glucose measurement apparatus even if the amount of change in the estimated blood glucose level has not reached or exceeded the preset non-invasive blood glucose threshold.

29. The blood glucose measurement system according to claim 28, wherein the controller comprises a register that can be written to from the outside, and the specific number of times can be changed according to the value of said register.

30. The blood glucose measurement system according to claim 1,

wherein the controller outputs the invasive actuation signal when the difference between the estimated blood glucose level and the blood glucose level measured by the invasive blood glucose measurement apparatus after calibration has reached or exceeded an abnormal blood glucose threshold.

31. The blood glucose measurement system according to claim 30,

wherein the blood glucose level estimator comprises a register that can be written to from the outside, and the abnormal blood glucose threshold can be changed according to the value of said register.

32. The blood glucose measurement system according to claim 1,

wherein the controller counts the number of times that the amount of change in the estimated blood glucose level after calibration has continuously reached or exceeded an abnormal blood glucose threshold, and outputs the invasive actuation signal when the continuous number of abnormal states has reached or exceeded a continuous abnormal state threshold.

33. The blood glucose measurement system according to claim 32,

wherein the blood glucose level estimator comprises a register that can be written to from the outside, and the continuous abnormal state threshold can be changed according to the value of said register.

34. A non-invasive blood glucose measurement apparatus in which a measured non-invasive blood glucose level is calibrated using a blood glucose level measured with an invasive blood glucose measurement apparatus that collects blood from the body and measures the blood glucose level on the basis of an invasive measurement command, the non-invasive blood glucose measurement apparatus comprising:

a controller that outputs a non-invasive actuation signal that instructs the non-invasive blood glucose measurement apparatus to detect a characteristic quantity in the body, and an invasive actuation signal that instructs the invasive blood glucose measurement apparatus to begin measuring a blood glucose level;

a characteristic quantity detector that detects the characteristic quantity in the body on the basis of the non-invasive actuation signal;

a blood glucose level estimator that finds an estimated blood glucose level on the basis of the characteristic quantity detected by the characteristic quantity detector and calibration data;

a blood glucose level calibration calculator that calculates calibration data from the blood glucose measurement information, including blood glucose levels, measured by the invasive blood glucose measurement apparatus, and the estimated blood glucose level found by the blood glucose level estimator; and

an invasive measurement command component that receives the invasive actuation signal outputted from the controller and instructs the invasive blood glucose measurement apparatus to measure the blood glucose level,

wherein the controller outputs the invasive actuation signal when the difference between the estimated blood glucose level and the blood glucose level measured by the invasive blood glucose measurement apparatus during calibration has reached or exceeded a preset non-invasive blood glucose threshold.