Adjustable left atrial appendage implant

• US 8,323,309 B2
• Filed: 05/19/2003
• Issued: 12/04/2012
• Est. Priority Date: 11/08/1999
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Atritech Inc. (Boston Scientific Corporation)
• Inventors: Khairkhahan, Alexander K., Frazier, Andrew G. C., Klenk, Alan R., Kreidler, Marc S., Kume, Stewart M., Ogi, Darrell H., Roue, Chad C., van der Burg, Erik J.
• Primary Examiner(s): McDermott, Corrine M
• Assistant Examiner(s): MASHACK, MARK F
• Application Number:
  US10/441,468
• Publication Number:
  US 20030204203A1
• Time in Patent Office: 3,487 Days
• Field of Search: 606/1, 606/108, 606/110, 606/113, 606/127, 606/151, 606190-200, 606/213, 606/139, 604/93.01, 604104-109, 128/887
• US Class Current: 606/200
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12122 within the heart for closing a cardiac septal defect A61B17/0057
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 2017/00575 for closure at remote site, e.g. closing atrial septum defects
• CPC Class Codes: A61B 2017/00579 Barbed implements
• CPC Class Codes: A61B 2017/00592 Elastic or resilient implements
• CPC Class Codes: A61B 2017/00597 Implements comprising a membrane
• CPC Class Codes: A61B 2017/00615 Implements with an occluder on one side of the opening and holding means therefor on the other
• CPC Class Codes: A61B 2017/00619 Locking means for locking the implement in expanded state
• CPC Class Codes: A61B 2017/00623 Introducing or retrieving devices therefor
• CPC Class Codes: A61B 2017/081 Tissue approximator A61B2017/1103, A61B17/8866 take precedence
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12095 Threaded connection
• CPC Class Codes: A61F 2/0108 Both ends closed, i.e. legs gathered at both ends
• CPC Class Codes: A61F 2/011 Instruments for their placement or removal
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/0006 : circular
• CPC Class Codes: A61F 2230/0071 : spherical
• CPC Class Codes: A61F 2230/008 : paraboloidal
• CPC Class Codes: A61M 2025/1054 : having detachable or disposable balloons
• CPC Class Codes: A61M 2210/125 : Heart
• CPC Class Codes: A61M 25/10 : Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

Disclosed is an adjustable occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device is removably carried by a deployment catheter. The device may be enlarged or reduced to facilitate optimal placement or removal. Methods are also disclosed.

Claims

1. An implantable device for positioning within the left atrial appendage of a patient, comprising:

an implant having a proximal hub, a distal hub, an intermediate hub and a longitudinal axis extending therebetween, the implant having a collapsed configuration and an expanded configuration;

a release element and a first receiving portion on the proximal hub of the implant sized and configured to releasably couple the implant to the release element;

wherein relative movement between the proximal hub and the distal hub of the implant causes the implant to move either from its collapsed configuration to its expanded configuration, or from its expanded configuration to its collapsed configuration, and

wherein the implant comprises a first apex portion between the proximal hub and said intermediate hub and a second apex portion between said intermediate hub and said distal hub, the implant in its expanded configuration increasing radially in dimension from the proximal hub to the first apex portion and then decreasing radially in dimension from the first apex portion to the intermediate hub; and

increasing radially in dimension from the intermediate hub to the second apex portion and then decreasing radially in dimension from the second apex portion to the distal hub;

wherein said first apex portion has a larger diameter than said second apex portion; and

a barrier permitting blood flow within the implant and attached to the implant proximal the intermediate hub, the barrier having a porosity within the range of from about 10 microns to about 100 microns.

2. The implantable device of claim 1 further comprising a set of barbs positioned on said first apex portion for interacting with the tissue of said left atrial appendage.

3. The implantable device of claim 1 wherein the implant comprises a frame element and the barrier at least in part comprises a first membrane on a first side of the frame element, a second membrane on the second side of the frame element and a bonding layer for bonding the first and second membranes togetheter.

4. The implantable device of claim 3 wherein the bonding layer comprises a porous structure having an open surface area within the range of from about 10% to about 90% open.

5. The implantable device of claim 3 wherein the frame element comprises a plurality of radially outwardly extending spokes.

6. The implantable device of claim 1 further comprising an elongate core and a second receiving portion on the distal end of the implant sized and configured to receive and prevent distal advancement of the elongate core past the distal end of the implant, the elongate core movable proximally from the implant, and wherein the implant is biased to the expanded configuration.

7. The implantable device of claim 6 further comprising a release element having a distal element disposed within the implant, the release element configured and attached to the implant such that the release element is movable proximally from the implant after the elongate core is moved proximally from the implant.

8. The implantable device of claim 7 wherein the release element distal end is looped around the core.

9. The implantable device of claim 8 further comprising a pin disposed in the receiving element, the release element disposed on only one side of the pin.

10. The implantable device of claim 6 wherein the second receiving portion comprises a guide tube having a closed distal end for non-fixedly receiving the core.