Methods of reducing retrograde flow

• US 8,323,332 B2
• Filed: 01/18/2010
• Issued: 12/04/2012
• Est. Priority Date: 03/01/2006
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Inventors: Agnew, Charles W.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): Sharma, Yashita
• Application Number:
  US12/689,101
• Publication Number:
  US 20100131053A1
• Time in Patent Office: 1,051 Days
• Field of Search: 623/1.24, 623 212- 214, 623 216- 218, 623/23.6, 623/23.68
• US Class Current: 623/1.24
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0066 stapled
• CPC Class Codes: A61F 2230/0026 trapezoidal
• CPC Class Codes: A61F 2230/0095 Saddle-shaped
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes

Abstract

Methods of reducing retrograde fluid flow through a valve within a body vessel are provided. The methods can include the steps of identifying a valve exhibiting an undesirable amount of retrograde fluid flow within a body vessel, such as a venous valve or a heart valve, and providing a means for reducing the retrograde fluid flow. A medical device providing a desired amount of retrograde fluid flow can be modified after permitting the medical device to remain in a body cavity for a remodeling-effective time period. The implanted medical device can be modified by subsequently reducing the amount of retrograde fluid flow permitted across the implanted prosthetic valve within the body vessel.

Claims

1. A method of reducing retrograde flow across a valve within a body cavity comprising the steps of:

a. an initial step of implanting a prosthetic valve having at least one leaflet comprising an extracellular matrix material and at least one aperture permitting retrograde fluid flow across the prosthetic valve;

b. permitting the implanted prosthetic valve to remain in the body cavity for a remodeling-effective period of time;

c. identifying the prosthetic valve within the body cavity comprising an aperture permitting retrograde fluid flow across the valve; and

d. implanting an occluding device after the remodeling-effective period of time, the occluding device comprising remodelable material in contact with the aperture of the valve within the body cavity to reduce the retrograde fluid flow across the valve.

2. The method of claim 1, wherein the remodelable material is an extracellular matrix material and the step of implanting the occluding device is performed with a percutaneous catheter within the body vessel.

3. The method of claim 2, wherein the extracellular matrix material comprises small intestine submucosa.

4. The method of claim 1, wherein the prosthetic valve is implanted within a vein.

5. The method of claim 1, wherein the prosthetic valve is a venous valve.

6. The method of claim 1, wherein the valve comprises a valve orifice moveable between an open position permitting fluid flow through the valve orifice and a closed position that substantially prevents fluid flow through the valve orifice;

and wherein the aperture permitting retrograde fluid flow across the valve is spaced from the valve orifice on the valve.