Bone implants

• US 8,323,348 B2
• Filed: 02/22/2005
• Issued: 12/04/2012
• Est. Priority Date: 02/22/2005
• Status: Active Grant

• Current Assignee: Taipei Medical University WAN Fan Hospital (Government of The Republic of China), Taiyen Biotech Co., Ltd.
• Original Assignee: Taiyen Biotech Co., Ltd.
• Inventors: Lai, Wen-Fu T., Pan, Li-Chern, Oung, Jung-Chou, Chen, Chun-Wei, Lim, Pau-Yee
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): SCHILLINGER, ANN M
• Application Number:
  US11/063,074
• Publication Number:
  US 20060190091A1
• Time in Patent Office: 2,842 Days
• Field of Search: 623/11, 623/16, 623/22, 623/23, 623/18, 433/201.1
• US Class Current: 623/23.5
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/06 Titanium or titanium alloys
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

This invention relates to a bone implant that includes a bioinert substrate covered with a ceramic layer containing a plurality of indentations. The total surface area of the indentations is 30-70% of the total surface area of the ceramic layer. This invention also relates to a method of preparing such a bone implant. The method includes: (1) affixing a ceramic layer on the surface of a bioinert substrate; (2) forming a plurality of indentations in the ceramic layer, wherein the total surface area of the indentations is 30-70% of the total surface area of the ceramic layer; and (3) immobilizing a biopolymer onto the ceramic layer via covalent bonding.

Claims

1. A bone implant comprising a bioinert substrate that includes a surface having a first portion and a second portion, the first portion containing small ridges, each of which has a width of 10-30 μ

m and a height of 10-30 μ

m, and the second portion containing large ridges, each of which has a width of 60-100 μ

m and a height of 40-80 μ

m, wherein the bone implant is configured such that, when it is placed at an implant site in a subject, the second portion is in contact with a bone.

2. The bone implant of claim 1, wherein each of the large ridges has a width of 70-90 μ

m and a height of 50-70 μ

m.

3. The bone implant of claim 1, wherein each of the small ridges has a width of 15-20 μ

m and a height of 15-20 μ

m.

4. The bone implant of claim 1, wherein the bioinert substrate is a metal-based substrate.

5. The bone implant of claim 4, wherein the substrate is a titanium alloy-based substrate.

6. The bone implant of claim 4, further comprising a metal oxide layer disposed on the bioinert substrate.

7. The bone implant of claim 6, wherein the second portion is covered with a ceramic layer that contains a plurality of indentations, the indentations occupying 30-70% of the total surface of the ceramic layer.

8. The bone implant of claim 7, wherein the ceramic layer is a hydroxyapetite layer.

9. The bone implant of claim 7, wherein the biopolymer is a collagen-based biopolymer.

10. The bone implant of claim 1, wherein the second portion is covered with a ceramic layer that contains a plurality of indentations, the indentations occupying 30-70% of the total surface of the ceramic layer.

11. The bone implant of claim 10, wherein the indentations occupy 50-60% of the total surface of the ceramic layer.

12. The bone implant of claim 10, wherein the ceramic layer is a hydroxyapetite layer.

13. The bone implant of claim 10, further comprising a biopolymer covalently bonded to the ceramic layer.

14. The bone implant of claim 10, further comprising a bone formation promoter covalently bonded to the ceramic layer.

15. A method of preparing a bone implant, comprising:

obtaining a bioinert substrate that has a surface with a first portion and a second portion, and,

forming on the first portion small ridges, each of which has a width of 10-30 μ

m and a height of 10-30 μ

m, and on the second portion large ridges, each having a width of 60-100 μ

m and a height of 40-80 μ

m,

wherein the bone implant is configured such that, when it is placed at an implant site in a subject, the second portion is in contact with a bone.

16. The method of claim 15, wherein the bioinert substrate is a metal-based substrate.

17. The method of claim 16, wherein the substrate is a titanium alloy-based substrate.

18. The method of claim 16, after the forming step, further comprising oxidizing the surface of the bioinert substrate to form a layer of metal oxides.

19. The method of claim 18, after the oxidizing step, further comprising:

affixing a ceramic layer on the second portion, and

generating a plurality of indentations in the ceramic layer,

wherein the indentations occupy 30-70% of the total surface of the ceramic layer.

20. The method of claim 19, wherein the ceramic layer is a hydroxyapetite layer.

21. The method of claim 19, after the generating step, further comprising immobilizing a biopolymer onto the ceramic layer via covalent bonding.

22. The method of claim 21, wherein the biopolymer is a collagen-based biopolymer.

23. The method of claim 19, after the generating step, further comprising covalently linking a bone formation promoter to the ceramic layer.