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Antibodies to IL-6 and use thereof

  • US 8,323,649 B2
  • Filed: 07/14/2009
  • Issued: 12/04/2012
  • Est. Priority Date: 11/25/2008
  • Status: Active Grant
First Claim
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1. A method of treating one or more symptoms of a disease or condition associated with elevated interleukin 6 (IL-6), comprising administration of an anti-human IL-6 antibody or antibody fragment to a subject in need thereof, wherein the anti-human IL-6 antibody or antibody fragment comprises:

  • a variable light (VL) region comprising the VL complementarity regions CDR1, CDR2 and CDR3, respectively having the sequences of SEQ ID NO;

    4, 5 and 6, and a variable heavy (VH) region comprising the VH complementarity regions CDR1, CDR2 and CDR3, respectively having the sequences of SEQ ID NO;

    7, 8 or 120 and 9; and

    wherein said anti-human IL-6 antibody or antibody fragment specifically binds to human IL-6 and antagonizes one or more activities associated with IL-6 in vivo, thereby treating one or more symptoms of said disease or condition associated with elevated interleukin 6 (IL-6).

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