Controlled vapor deposition of biocompatible coatings for medical devices
First Claim
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1. A method for providing an intraocular lens surface with a hydrophilic polymer coating comprising:
- applying at least one hydrophilic polymer coating to at least one surface of said intraocular lens using vapor deposition,wherein the vapor deposition comprises the steps of;
a) exposing a surface of the intraocular lens to an oxygen-comprising plasma in a processing chamber which is at subatmospheric pressure;
b) subsequently, without exposure of said oxygen-comprising plasma treated surface to ambient conditions which contaminate or react with said plasma treated surface, exposing said surface to a silicon chloride containing vapor in the presence of moisture, to form a hydrophilic silicon oxide layer on said surface; and
c) subsequently, without exposure of said hydrophilic silicon oxide layer to ambient conditions which contaminate or react with said hydrophilic silicon oxide layer, exposing said silicon oxide layer to a polyethylene glycol polymer having a plurality of monomers to form a layer selected from the group consisting of a monolayer, a self-aligned monolayer, and a polymerized cross-linked layer, wherein of the monomers have a structure of Formula 1;
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Abstract
An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition.
42 Citations
3 Claims
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1. A method for providing an intraocular lens surface with a hydrophilic polymer coating comprising:
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applying at least one hydrophilic polymer coating to at least one surface of said intraocular lens using vapor deposition, wherein the vapor deposition comprises the steps of; a) exposing a surface of the intraocular lens to an oxygen-comprising plasma in a processing chamber which is at subatmospheric pressure; b) subsequently, without exposure of said oxygen-comprising plasma treated surface to ambient conditions which contaminate or react with said plasma treated surface, exposing said surface to a silicon chloride containing vapor in the presence of moisture, to form a hydrophilic silicon oxide layer on said surface; and c) subsequently, without exposure of said hydrophilic silicon oxide layer to ambient conditions which contaminate or react with said hydrophilic silicon oxide layer, exposing said silicon oxide layer to a polyethylene glycol polymer having a plurality of monomers to form a layer selected from the group consisting of a monolayer, a self-aligned monolayer, and a polymerized cross-linked layer, wherein of the monomers have a structure of Formula 1; - View Dependent Claims (2, 3)
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Specification
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Current AssigneeJohnson & Johnson Surgical Vision, Inc. (Johnson & Johnson)
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Original AssigneeBoris Kobrin, Jeffrey D. Chinn, Laurent Hoffmann, Michael D. Lowery, Richard C. Yi, Romuald Nowak
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InventorsLowery, Michael D, Hoffmann, Laurent, Kobrin, Boris, Nowak, Romuald, Chinn, Jeffrey D, Yi, Richard C
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Primary Examiner(s)Meeks, Timothy
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Assistant Examiner(s)SELLMAN, CACHET I
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Application NumberUS13/107,243Publication NumberTime in Patent Office571 DaysField of Search427 21- 231, 427/248.1, 427/248.15, 427/255.11, 427/255.14, 427/255.18, 427/2.24, 623/6.11, 623/6.62US Class Current427/2.24CPC Class CodesA61L 27/34 Macromolecular materialsA61L 29/085 Macromolecular materialsA61L 31/10 Macromolecular materialsB82Y 30/00 Nanotechnology for material...B82Y 40/00 Manufacture or treatment of...C08L 71/02 Polyalkylene oxidesY10T 428/261 In terms of molecular thick...Y10T 428/31667 Next to addition polymer fr...
