Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
First Claim
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1. A method of normalizing the expression levels of a plurality of cardiac genes comprising determining that a patient has a cardiac disease associated with abnormal gene expression in a plurality of cardiac genes;
- and applying an electric field to diseased cardiac cells in an in-vivo heart using suitable parameters and for a sufficient duration to have said normalization effect on the expression levels of said plurality of cardiac genes in said diseased cardiac cells.
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Abstract
Method and apparatus for modifying gene expression in cardiac muscle cells, by the application of electric fields. In some embodiments, the modification provides treatment of heart failure. Optionally, the treatment also provides an immediate improvement in cardiac function.
469 Citations
47 Claims
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1. A method of normalizing the expression levels of a plurality of cardiac genes comprising determining that a patient has a cardiac disease associated with abnormal gene expression in a plurality of cardiac genes;
- and applying an electric field to diseased cardiac cells in an in-vivo heart using suitable parameters and for a sufficient duration to have said normalization effect on the expression levels of said plurality of cardiac genes in said diseased cardiac cells.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A method of programming a cardiac stimulator, comprising:
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(a) determining a desired normalization effect of said stimulator on at least two cardiac genes for treating a cardiac disease associated with abnormal gene expression in a plurality of cardiac genes; and (b) programming said stimulator with signal application parameters suitable for providing said normalization effect on the expression levels of said at least two cardiac genes in said diseased cardiac cells. - View Dependent Claims (42, 43, 44, 45, 46)
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47. A method of normalizing the expression levels of a plurality of cardiac genes comprising applying an electric field to in an in-vivo heart using suitable parameters and for a sufficient duration to have said normalization effect, wherein said normalization comprises normalization to within 30% of baseline levels.
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