Bladder arrangement for microneedle-based drug delivery device

• US 8,328,757 B2
• Filed: 01/08/2010
• Issued: 12/11/2012
• Est. Priority Date: 01/08/2010
• Status: Active Grant

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Beebe, David J., Moga, Benjamin J., Chase, Kent B., Smith, Garrick D. S., Myre, Jake W.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): CHANDER, DIVA KAKAR
• Application Number:
  US12/684,566
• Publication Number:
  US 20110172601A1
• Time in Patent Office: 1,068 Days
• Field of Search: 604/132, 604/133, 604/131
• US Class Current: 604/131
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

A bladder arrangement is provided for a microneedle-based drug delivery device. The bladder arrangement includes a flexible membrane having an inner surface, an outer surface and an outer periphery. A bladder member, having a rigidity greater than the flexible membrane, includes an inner surface, an outer surface and an outer periphery. The inner surface of the flexible membrane and the inner surface of the bladder member define a chamber for receiving a drug therein. At least one microneedle is operatively connected to the bladder member. The at least one microneedle has an input and an output receivable within the individual. A valve operatively connects the input of the at least one microneedle and the chamber.

Claims

1. A bladder arrangement for an active transdermal drug delivery device, comprising:

a first flexible membrane having an inner and outer surface;

a bladder member including an inner surface, an outer surface and an aperture therethrough, the inner surface of the flexible membrane and the inner surface of the bladder member defining a chamber for receiving a drug therein;

an array of microneedles, each microneedle having an input;

a valve arrangement received within the aperture in the bladder member and communicating with the inputs of the microneedles through a passageway, the valve arrangement movable between a first configuration wherein the inputs of the microneedles are isolated from the drug in the chamber and a second configuration wherein the passageway communicates with the drug in the chamber;

a pressure source engageable with the flexible membrane, the pressure source having a first retracted configuration and a second expanded configuration wherein the pressure source urges the drug from the chamber towards the passageway; and

an actuator movable between a first non-actuated position and a second actuated position;

wherein;

the pressure source moves to the expanded configuration in response to the movement of the actuator to the actuated position;

the valve arrangement moves from the first configuration to the second configuration in response to the movement of the actuator to the actuated position; and

at least a portion of the bladder member defining the aperture is rigid.

2. The bladder arrangement of claim 1 wherein:

the first flexible membrane has an outer periphery;

the bladder member has an outer periphery; and

the outer periphery of the first flexible membrane and the outer periphery of the bladder member are bonded to form a hermetic seal.

3. The bladder arrangement of claim 1 wherein the bladder member includes an opening therethrough for allowing the drug to be injected into the chamber and wherein the bladder arrangement further comprises a plug receivable in the opening in the bladder matter for maintaining the drug in the chamber.

4. The bladder arrangement of claim 1 wherein the valve arrangement includes a check valve, the check valve allowing the drug to flow in a first direction from the chamber to the passageway and preventing fluid flow in a second direction from the passageway to the chamber.

5. A bladder arrangement for a drug delivery device, comprising:

a flexible membrane having an inner surface, an outer surface and an outer periphery;

a bladder member including an inner surface, an outer surface, an aperture extending therethrough and an outer periphery bonded to the outer periphery of the flexible membrane, the inner surface of the flexible membrane and the inner surface of the bladder member defining a chamber for receiving a drug therein;

an array of microneedles, each microneedle having an input communicating with a passageway; and

a valve arrangement received in the aperture for controlling the flow of the drug from the chamber to the passageway, the valve arrangement movable between a first configuration wherein the inputs of the microneedles are is isolated from the drug in the chamber and a second configuration wherein the passageway communicates with the drug in the chamber;

a pressure source engageable with the flexible membrane, the pressure source having a first retracted configuration and a second expanded configuration wherein the pressure source urges the drug from the chamber towards the passageway; and

an actuator movable between a first non-actuated position and a second actuated position;

wherein;

the pressure source moves to the expanded configuration in response to the movement of the actuator to the actuated position;

the valve arrangement moves from the first configuration to the second configuration in response to the movement of the actuator to the actuated position; and

at least a portion the bladder member defining the aperture is rigid.

6. The bladder arrangement of claim 5 wherein the outer periphery of the flexible membrane and the outer periphery of the bladder member are bonded to form a hermetic seal.

7. The bladder arrangement of claim 5 wherein the bladder member includes an opening therethrough for allowing the drug to be injected into the chamber and wherein the bladder arrangement further comprises a plug receivable in the opening in the bladder matter for maintaining the drug in the chamber.

8. The bladder arrangement of claim 5 wherein the valve arrangement includes a check valve, the check valve allowing the drug to flow in a first direction from the chamber to the passageway and preventing fluid flow in a second direction from the passageway to the chamber.

9. The bladder arrangement of claim 5 wherein the pressure source includes an expandable hydrogel, the hydrogel applying pressure on the flexible member as the hydrogel expands.

10. A bladder arrangement for a drug delivery device, comprising:

a flexible membrane having an inner surface, an outer surface and an outer periphery;

a bladder member having an aperture therethough and including an inner surface, an outer surface and an outer periphery, the inner surfaces of the flexible membrane and the inner surface of the bladder member defining a chamber for receiving a drug therein;

an array of microneedles having inputs communicating with a passageway and outputs receivable within the individual; and

a valve received in the aperture in the bladder member and operatively connecting the passageway and the chamber, the valve movable between a first configuration wherein the inputs of the microneedles are is isolated from the drug in the chamber and a second configuration wherein the passageway communicates with the drug in the chamber;

a pressure source engageable with the flexible membrane, the pressure source having a first retracted configuration and a second expanded configuration wherein the pressure source urges the drug from the chamber towards the passageway; and

an actuator movable between a first non-actuated position and a second actuated position;

wherein;

the pressure source moves to the expanded configuration in response to the movement of the actuator to the actuated position;

the valve moves from the first configuration to the second configuration in response to the movement of the actuator to the actuated position; and

the entirety of the bladder member is rigid.

11. The bladder arrangement of claim 10 wherein the outer periphery of the flexible membrane and the outer periphery of the bladder member are bonded to form a hermetic seal.

12. The bladder arrangement of claim 10 wherein the bladder member includes an opening therethrough for allowing the drug to be injected into the chamber and wherein the bladder arrangement further comprises a plug receivable in the opening in the bladder member for maintaining the drug in the chamber.

13. The bladder arrangement of claim 10 wherein the valve is a check valve, the check valve allowing the drug to flow in a first direction from the chamber to the passageway and preventing fluid flow in a second direction from the passageway to the chamber.

14. The bladder arrangement of claim 10 further comprising a docking station for supporting the array of microneedles, the docking station being removably connected to the bladder member.