Methods and compositions for the prevention and treatment of sepsis
First Claim
1. A composition for administration to a patient in need thereof for the prevention or treatment of sepsis comprising a complement inhibitor, and a CD14 pathway inhibitor,wherein the complement inhibitor is an anti-C5a antibody or a binding fragment thereof,wherein the CD14 pathway inhibitor is an anti-CD14 antibody or a binding fragment thereof,wherein the sepsis is induced by gram negative bacteria, andwherein the composition can be administered by oral, rectal, nasal, topical, intradermal, subcutaneous, intravenous, intramuscular, intratracheal, or intraperitoneal means.
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Accused Products
Abstract
The present invention includes compositions comprising one or more complement inhibitors and one or more CD14 pathway inhibitors for the prevention or treatment of sepsis. The complement inhibitors may be antibodies that bind to and inhibit complement proteins such as C5a and the CD14 pathway inhibitors may be antibodies that bind to and inhibit CD14 pathway components, such as CD14 and LPS. The invention also relates to methods of treating subjects suffering from sepsis comprising administering these compositions, as well as kits for supplying the compositions for treatment.
47 Citations
13 Claims
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1. A composition for administration to a patient in need thereof for the prevention or treatment of sepsis comprising a complement inhibitor, and a CD14 pathway inhibitor,
wherein the complement inhibitor is an anti-C5a antibody or a binding fragment thereof, wherein the CD14 pathway inhibitor is an anti-CD14 antibody or a binding fragment thereof, wherein the sepsis is induced by gram negative bacteria, and wherein the composition can be administered by oral, rectal, nasal, topical, intradermal, subcutaneous, intravenous, intramuscular, intratracheal, or intraperitoneal means.
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3. A composition for administration to a patient in need thereof for the prevention or treatment of sepsis, comprising a bispecific antibody comprising a first binding element that binds C5a and a second binding element that binds CD14,
wherein the sepsis is induced by gram negative bacteria, and wherein the composition can be administered by oral, rectal, nasal, topical, intradermal, subcutaneous, intravenous, intramuscular, intratracheal, or intraperitoneal means.
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5. A kit for administration to a patient in need thereof for the prevention or treatment of sepsis, comprising a complement inhibitor and a CD14 pathway inhibitor, in separate containers,
wherein the complement inhibitor is an anti-C5a antibody or a binding fragment thereof, wherein the CD14 pathway inhibitor is an anti-CD 14 antibody or a binding fragment thereof, wherein the sepsis is induced by gram negative bacteria, and wherein the complement inhibitor and CD14 pathway inhibitor can be administered by oral, rectal, nasal, topical, intradermal, subcutaneous, intravenous, intramuscular, intratracheal, or intraperitoneal means.
Specification