Dual controlled release dosage form
First Claim
Patent Images
1. A dual controlled release osmotic device comprising:
- a) a core comprising a first active agent-containing controlled release layer and a second active agent-containing controlled release layer in direct contact therewith, wherein the second active agent-containing layer surrounds the first active agent-containing layer; and
the osmotic device excludes a push-layer; and
b) a membrane surrounding the core, wherein the membrane comprises at least one preformed passageway in communication with at least one of the first and second active agent-containing controlled release layers;
whereby the osmotic device provides a controlled release of the first active agent through the at least one preformed passageway according to a first release profile and the second layer provides a controlled release of the second active through the at least one preformed passageway according to a second release profile, and wherein the first drug and the second drug are released sequentially when the device is exposed to an aqueous environment of use.
5 Assignments
0 Petitions
Accused Products
Abstract
A dosage form that provides a controlled release of at least two different active agents is provided. Particular embodiments include a dosage form that provides therapeutically effective levels of a first active agent and a second active agent in a mammal for an extended period of time following oral administration. An osmotic device containing a bi-layered core is provided. The osmotic device provides a dual controlled release of both drugs from the core. The layers of the core are in stacked, substantially concentric or substantially eccentric arrangement.
-
Citations
33 Claims
-
1. A dual controlled release osmotic device comprising:
-
a) a core comprising a first active agent-containing controlled release layer and a second active agent-containing controlled release layer in direct contact therewith, wherein the second active agent-containing layer surrounds the first active agent-containing layer; and
the osmotic device excludes a push-layer; andb) a membrane surrounding the core, wherein the membrane comprises at least one preformed passageway in communication with at least one of the first and second active agent-containing controlled release layers;
whereby the osmotic device provides a controlled release of the first active agent through the at least one preformed passageway according to a first release profile and the second layer provides a controlled release of the second active through the at least one preformed passageway according to a second release profile, and wherein the first drug and the second drug are released sequentially when the device is exposed to an aqueous environment of use. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
-
Specification