Composition containing short-to-ultrashort GPIIb/IIIa and factor Xa inhibitors and platelets
First Claim
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1. A preserved platelet preservation composition, comprising:
- a) an antiplatelet agent;
b) an anticoagulant; and
c) plateletswherein said antiplatelet agent comprises a short-to-ultrashort GPIIb/IIIA inhibitor, wherein said anticoagulant comprises a short-to-ultrashort acting factor Xa inhibitor and wherein said composition is capable of extending the shelf-life of said platelets.
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Abstract
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
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18 Claims
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1. A preserved platelet preservation composition, comprising:
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a) an antiplatelet agent; b) an anticoagulant; and c) platelets wherein said antiplatelet agent comprises a short-to-ultrashort GPIIb/IIIA inhibitor, wherein said anticoagulant comprises a short-to-ultrashort acting factor Xa inhibitor and wherein said composition is capable of extending the shelf-life of said platelets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of extending the shelf-life of platelets, comprising the steps of:
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(a) admixing a preservative composition with unactivated, functional platelets to provide a preserved platelet composition; and (b) storing the preserved platelet composition in an oxygen-permeable container or an oxygen-impermeable container, wherein the preservative composition comprises an antiplatelet agent and an anticoagulant, wherein said antiplatelet agent comprises a short-to-ultrashort acting GPIIb/IIIA inhibitor, and wherein said anticoagulant comprises a short-to-ultrashort factor Xa inhibitor. - View Dependent Claims (17, 18)
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Specification