Isatin analogues and uses therefor
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Abstract
Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
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Citations
7 Claims
- 1. An isatin analogue of structure
- 3. An isatin analogue of structure
- 6. An Isatin Michael Acceptor (IMA) selected from the group
Specification