Methods for treatment of hyperhidrosis

• US 8,333,700 B1
• Filed: 09/04/2012
• Issued: 12/18/2012
• Est. Priority Date: 10/06/2004
• Status: Active Grant

• Current Assignee: Guided Therapy Systems Llc
• Original Assignee: Guided Therapy Systems Llc
• Inventors: Barthe, Peter G., Slayton, Michael H., Makin, Inder Raj S.
• Primary Examiner(s): Peffley, Michael
• Assistant Examiner(s): Hupczey, Jr., Ronald
• Application Number:
  US13/603,159
• Publication Number:
  US 20120330222A1
• Time in Patent Office: 105 Days
• Field of Search: 600437-439, 606/27, 606/41, 128/898
• US Class Current: 600/439
• CPC Class Codes: A61B 17/320068 using mechanical vibrations, e.g. ultrasonic A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745
• CPC Class Codes: A61B 2017/320069 for ablating tissue
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue
• CPC Class Codes: A61N 2007/0004 Applications of ultrasound therapy
• CPC Class Codes: A61N 2007/0052 using the same transducer for therapy and imaging
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Methods for ultrasound treatment of hyperhidrosis are provided. Various methods and systems for targeted treatment of sweat glands can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound through control of various spatial and temporal parameters. As a result, thermal and/or ablative energy can be deposited at the particular depth at which the sweat gland population is located below the skin surface. Ultrasound and non-ultrasound treatments for hyperhidrosis are provided.

Claims

1. A method for reducing sweat, the method comprising:

positioning an ultrasound probe on a skin surface, the ultrasound probe comprising at least one ultrasound therapy element;

targeting a region of interest under the skin surface, wherein the region of interest comprises a sweat gland;

using the at least one ultrasound therapy element to create a plurality of thermal lesions to thermally ablate the sweat gland in the region of interest to reduce sweat,

wherein the at least one ultrasound therapy element is configured to deliver ultrasound energy at a depth below the skin surface.

2. The method of claim 1, wherein the at least one ultrasound therapy element is configured to deliver ultrasound energy at a depth of about 1 mm to about 7 mm below the skin surface.

3. The method of claim 1, wherein the using the at least one ultrasound therapy element comprises destroying the sweat gland within a specified treatment depth identified through localization of the sweat gland.

4. The method of claim 1, further comprising controlling at least one of a spatial parameter and a temporal parameter of the ultrasound probe to generate the plurality of thermal lesions in desired shapes, sizes, or orientations in at least a portion of the region of interest.

5. The method of claim 1, further comprising using an automated motion mechanism to move the at least one ultrasound therapy element.

6. The method of claim 1, wherein the using the at least one ultrasound therapy element comprises using electronic phase focusing of the at least one ultrasound therapy element to position a focus for delivery of the ultrasound energy to create at least one of the plurality of thermal lesions in the sweat gland.

7. The method of claim 1, wherein the step of creating the plurality of thermal lesions comprises producing a one-, two- or three-dimensional matrix of spaced lesions in the region of interest to reduce sweat.

8. The method of claim 1, further comprising imaging a region below the skin surface.

9. The method of claim 1, further comprising monitoring a region treated by the ultrasound therapy element for further planning, assessing of results, or providing feedback.

10. The method of claim 1, further comprising administering a pharmaceutical agent to the region of interest to further reduce sweat.

11. The method of claim 1, wherein the at least one ultrasound therapy element delivers energy at a frequency in a range of 500 kHz to 15 MHz.

12. The method of claim 1, wherein the at least one ultrasound therapy element comprises a plurality of ultrasound therapy elements.

13. The method of claim 1, further comprising a second probe configured to deliver a treatment selected from the group consisting of one or more of the following:

ultrasound, radio frequency (RF), laser, and microwave.

14. The method of claim 1, wherein the sweat gland is located in an area selected from the group consisting of one or more of the following:

a face, an armpit, a palm, and a sole.

15. A method for reducing sweat by thermally lesioning at least one sweat gland, the method comprising:

identifying a subject having a region of interest comprising at least one sweat gland;

placing an ultrasound probe on a skin surface overlying the region of interest;

targeting therapeutic acoustic waves, via at least one ultrasound treatment element housed within the ultrasound probe, through the skin surface to the region of interest to create a plurality of thermal lesions along a line at a depth of about 1 mm to about 7 mm below the skin surface,

wherein the line of lesions is generated using an automated motion mechanism that controls motion of the at least one ultrasound treatment element.

16. The method of claim 15, further comprising imaging the region of interest.

17. The method of claim 15, wherein the at least one sweat gland is located an area selected from the group consisting of one or more of the following:

a face, an armpit, a palm, and a sole.

18. A method for reducing sweat, the method comprising:

transmitting ultrasonic energy, via an ultrasound element, to create a first ablative lesion in a first sweat gland; and

moving the ultrasound element, via a motion mechanism, to create a second ablative lesion in a second sweat gland

wherein the first and second ablative lesions reduce the amount of sweat produced from the first and second sweat glands.

19. The method of claim 18, wherein the first and second ablative lesions are created along a linear path.

20. The method of claim 18, further comprising imaging a region of interest comprising at least the first sweat gland.