Rotatable catheter assembly

• US 8,333,784 B2
• Filed: 04/12/2010
• Issued: 12/18/2012
• Est. Priority Date: 02/24/2004
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Eidenschink, Tracee
• Primary Examiner(s): Nguyen, Victor
• Application Number:
  US12/758,561
• Publication Number:
  US 20100191221A1
• Time in Patent Office: 981 Days
• Field of Search: 606/108, 606/192, 606/194, 606/198, 604/96.01, 604/99.04, 604/104, 604/509, 623/1.11
• US Class Current: 606/194
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/954 for placing stents or stent-grafts in a bifurcation
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/008 Phase change materials [PCM], e.g. for storing latent heat
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas
• CPC Class Codes: A61M 2025/0058 having an electroactive polymer material, e.g. for steering purposes, for control of flexibility, for locking, for opening or closing
• CPC Class Codes: A61M 2025/1015 having two or more independently movable balloons where the distance between the balloons can be adjusted, e.g. two balloon catheters concentric to each other forming an adjustable multiple balloon catheter system
• CPC Class Codes: A61M 2025/1056 having guide wire lumens outside the main shaft, i.e. the guide wire lumen is within or on the surface of the balloon

Abstract

A catheter assembly includes a catheter shaft, a balloon and a pair of collars. The collars may be fixed or rotatable about a catheter shaft prior to exposure to an electric current. Where the collars are fixed to the shaft, the balloon is rotatable about the collars. When exposed to the electric current the collars expand to engage the waists of the balloon thereby sealing the balloon. Where the collars are rotatable about the shaft, each waist of the balloon is engaged to a respective collar. When the rotatable collars are exposed to the electric current the collars expand to engage the shaft of the catheter thereby sealing the balloon.

Claims

1. A medical device, comprising:

an elongate shaft including a proximal region, a distal region, and a lumen extending at least partially therebetween;

a balloon disposed about the distal region of the elongate shaft, the balloon comprising an electroactive polymer, wherein the electroactive polymer is configured to be electrically actuated between a non-activated configuration and an activated configuration, wherein the activated configuration is different than the non-activated configuration;

a current source configured to provide an electrical current for selectively electrically actuating the electroactive polymer;

a conductive member in electrical communication with the current source and the electroactive polymer, wherein the conductive member is configured to transmit the electrical current from the current source to the electroactive polymer, wherein the conductive member extends along at least a portion of the distal region of the elongate shaft; and

one or more therapeutic agents, wherein the medical device is configured to deliver the one or more therapeutic agents to a delivery site within a vessel;

wherein the one or more therapeutic agents is at least one non-genetic therapeutic agent selected from at least one member of the group consisting of;

anti-thrombogenic agents including heparin, heparin derivatives, urokinase, and PPack (dextrophenylalanine proline arginine chloromethylketone);

anti-proliferative agents including enoxaprin, angiopeptin, monoclonal antibodies capable of blocking smooth muscle cell proliferation, hirudin, and acetylsalicylic acid;

anti-inflammatory agents including dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, and mesalamine;

antineoplastic/antiproliferative/anti-miotic agents including paclitaxel, 5-fluorouracil, cisplatin, vinblastine, vincristine, epothilones, endostatin, angiostatin and thymidine kinase inhibitors;

anesthetic agents including lidocaine, bupivacaine and ropivacaine;

anti-coagulants including D-Phe-Pro-Arg chloromethyl keton, an RGD peptide-containing compound, heparin, antithrombin compounds, platelet receptor antagonists, anti-thrombin antibodies, anti-platelet receptor antibodies, aspirin, prostaglandin inhibitors, platelet inhibitors and tick antiplatelet peptides;

vascular cell growth promoters including growth factor inhibitors, growth factor receptor antagonists, transcriptional activators, and translational promoters;

vascular cell growth inhibitors including growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors, translational repressors, replication inhibitors, inhibitory antibodies, antibodies directed against growth factors;

bifunctional molecules consisting of a growth factor and a cytotoxin;

bifunctional molecules consisting of an antibody and a cytotoxin;

cholesterol-lowering agents;

vasodilating agents;

agents which interfere with endogenous vascoactive mechanisms, and any combinations thereof.

2. The medical device of claim 1, wherein the electroactive polymer is in the activated configuration when exposed to the electrical current, and wherein the electroactive polymer is in the non-activated state when not exposed to the electrical current.

3. The medical device of claim 1, wherein the activated configuration of the electroactive polymer is an expanded configuration relative to the non-expanded configuration.

4. The medical device of claim 1, wherein the conductive member is at least partially enclosed by the elongate shaft.

5. The medical device of claim 1, wherein the conductive member is co-extruded with the elongate shaft.

6. The medical device of claim 1, wherein the electroactive polymer includes a material selected from at least one member of the group consisting of:

Poly-pyrrole (PPY), Poly-Aniline (PAni), Poly-Thiofene (PTH), Poly-Paraphenylene Vinylene (PPV), Nafion®

, Bucky paper, and any combination thereof.

7. The medical device of claim 1, wherein the balloon includes one or more collars comprising the electroactive polymer.

8. A medical device, comprising:

an elongate shaft including a proximal region, a distal region, and a lumen extending at least partially therebetween;

a balloon disposed about the distal region of the elongate shaft, the balloon comprising an electroactive polymer, wherein the electroactive polymer is configured to be electrically actuated between a non-activated configuration and an activated configuration, wherein the activated configuration is an expanded configuration relative to the non-activated configuration;

a current source configured to provide an electrical current for selectively electrically actuating the electroactive polymer;

a conductive member in electrical communication with the current source and the electroactive polymer, wherein the conductive member is configured to transmit the electrical current from the current source to the electroactive polymer, wherein the conductive member extends along at least a portion of the distal region of the elongate shaft; and

one or more therapeutic agents for treating a vessel, wherein the medical device is configured to deliver the one or more therapeutic agents to a delivery site within a vessel;

wherein the one or more therapeutic agents is at least one non-genetic therapeutic agent selected from at least one member of the group consisting of;

anti-thrombogenic agents including heparin, heparin derivatives, urokinase, and PPack (dextrophenylalanine proline arginine chloromethylketone);

anti-proliferative agents including enoxaprin, angiopeptin, monoclonal antibodies capable of blocking smooth muscle cell proliferation, hirudin, and acetylsalicylic acid;

anti-inflammatory agents including dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, and mesalamine;

antineoplastic/antiproliferative/anti-miotic agents including paclitaxel, 5-fluorouracil, cisplatin, vinblastine, vincristine, epothilones, endostatin, angiostatin and thymidine kinase inhibitors;

anesthetic agents including lidocaine, bupivacaine and ropivacaine;

anti-coagulants including D-Phe-Pro-Arg chloromethyl keton, an RGD peptide-containing compound, heparin, antithrombin compounds, platelet receptor antagonists, anti-thrombin antibodies, anti-platelet receptor antibodies, aspirin, prostaglandin inhibitors, platelet inhibitors and tick antiplatelet peptides;

vascular cell growth promoters including growth factor inhibitors, growth factor receptor antagonists, transcriptional activators, and translational promoters;

vascular cell growth inhibitors including growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors, translational repressors, replication inhibitors, inhibitory antibodies, antibodies directed against growth factors;

bifunctional molecules consisting of a growth factor and a cytotoxin;

bifunctional molecules consisting of an antibody and a cytotoxin;

cholesterol-lowering agents;

vasodilating agents;

agents which interfere with endogenous vascoactive mechanisms, and any combinations thereof.

9. The medical device of claim 8, wherein the electroactive polymer is in the activated configuration when exposed to the electrical current, and wherein the electroactive polymer is in the non-activated state when not exposed to the electrical current.

10. The medical device of claim 8, wherein the conductive member is at least partially enclosed by the elongate shaft.

11. The medical device of claim 8, wherein the conductive member is co-extruded with the elongate shaft.

12. The medical device of claim 8, wherein the therapeutic agent includes at least one polymer agent or coating.