Test cartridge holder for blood samples

• US 8,333,938 B2
• Filed: 05/23/2007
• Issued: 12/18/2012
• Est. Priority Date: 02/20/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Green, Michael M., Nippoldt, Douglas D., Zillmann, William D., Wallace, Brent E., Rejent, Jeff N.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Handy, Dwayne K
• Application Number:
  US11/752,743
• Publication Number:
  US 20080009073A1
• Time in Patent Office: 2,036 Days
• Field of Search: 422 99-104, 422/500, 422/560, 422/561, 422/562, 422/566, 436 66- 70, 436/174, 436/179, 436/180, 604/68, 604/154, 604/155
• US Class Current: 422/561
• CPC Class Codes: B01L 2200/026 Fluid interfacing between devices or objects, e.g. connectors, inlet details
• CPC Class Codes: B01L 2300/0654 Lenses; Optical fibres
• CPC Class Codes: B01L 3/0293 for liquids
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: B01L 9/00 Supporting devices; Holding devices
• CPC Class Codes: Y10T 436/25 including sample preparation
• CPC Class Codes: Y10T 436/25625 Dilution
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

Improved methods and apparatus that make more accurate and reduces risk of filling reaction chambers of cartridge cells with blood samples to conduct blood coagulation tests of the type employing the plunger technique are disclosed. A cartridge holder is provided that secures a test cartridge in a fixed upright position and deflects the plunger flag of each cartridge cell to enable manual insertion of a blood dispenser deeply into the reaction chamber to fill the reaction chamber and avoid contamination of surfaces of the cartridge outside the reaction chamber. Preferably, the cartridge holder provides illumination of the reaction chamber during filling, so that the user can judge when the reaction chamber is properly filled with blood dispensed from the blood dispenser. The cartridge holder may incorporate image magnification to facilitate viewing of the reaction chamber as it is filled.

Claims

1. A cartridge holder for facilitating filling at least one cartridge cell of a test cartridge with a blood sample dispensed from a blood sample dispenser through an upper end opening of a reaction chamber of the cartridge cell for conducting a blood coagulation test, the cartridge cell employing a plunger that is lifted during mixture of the blood sample with a reagent by engagement of a lift mechanism with a plunger upper end that extends from the cartridge cell, the cartridge holder comprising:

a cartridge holder frame comprising a lower base and a rear frame configured to provide a test cartridge receptacle that receives and supports the cartridge cell in an upright position, the lower base forming a floor of a fixed lower cartridge cell supporting and receiving structure that defines a lower portion of the upright position of the cartridge cell; and

a plunger upper end deflector that defines an upper portion of the upright position of the cartridge cell and comprises a deflecting arm that extends at an angle from the rear frame over the lower cartridge cell supporting and receiving structure of the base to engage and deflect the plunger upper end to a side of the cartridge cell when positioned in the upright position of the test cartridge receptacle,

wherein a distance between the plunger upper end deflector and the lower base is configured to accommodate a total height of the cartridge cell.

2. The test cartridge holder of claim 1, wherein base member is configured to support a pair of cartridge cells and comprises a first recess and a second recess parallel to the first recess as first and second lower cartridge cell supporting and receiving structure, and wherein the plunger upper end deflector comprises a second deflecting arm extending at an angle from the rear frame over the second lower cartridge cell supporting and receiving structure to engage and deflect the plunger upper end of a second cartridge cell when positioned within the upright position of a second test cartridge receptacle.

3. The test cartridge holder of claim 1, wherein the rear frame comprises a light emitter configured to extend behind and illuminate the cartridge cell when positioned in an upright position in the cartridge holder.

4. The test cartridge holder of claim 3, wherein the light emitter is a transparent panel, a translucent panel, or an electroluminescent flat panel.

5. The test cartridge holder of claim 1, further comprising an optical lens.

6. The test cartridge holder of claim 5, wherein the lens is supported by the rear frame and disposed with respect to the test cartridge receptacle.

7. The test cartridge of claim 5, wherein the rear frame comprises the optical lens.

8. The test cartridge holder of claim 1, further comprising a lens cover.

9. The test cartridge holder of claim 8, wherein the lens cover comprises a front panel coupled to a first and second side panel.

10. The test cartridge holder of claim 9, wherein the front panel comprises a first guide and a second guide.

11. The test cartridge holder of claim 9, wherein the front panel comprises an optical lens.

12. The test cartridge holder of claim 8, wherein the lens cover comprises a transparent material.

13. The test cartridge holder of claim 8, wherein the lens cover is adapted to be disposed in front of a test cartridge cell that is inserted in the test cartridge receptacle.

14. A method comprising:

providing a test cartridge cell having a plunger including a shaft having a first end and a second end, wherein a flag is disposed on the first end;

inserting the test cartridge cell into a test cartridge holder having a fixed base member, a rear frame that extends from the base member, wherein the rear frame includes a test cartridge receptacle adapted to receive and support the test cartridge cell in an upright position, a first deflecting arm and a second deflecting arm, wherein the arms extend from the rear frame so that the first end of the plunger is deflected to a side of the test cartridge cell upon insertion; and

dispensing a physiological sample into the cell.

15. The method of claim 14, wherein the physiological sample comprises blood or a component thereof.

16. The method of claim 14, further comprising illuminating the test cartridge cell.

17. The method of claim 16, wherein the illuminating comprises the use of diffuse light.

18. The method of claim 16, wherein the test cartridge cell is illuminated during the dispensing of the physiological sample.

19. The method of claim 14, further comprising magnifying the test cartridge cell.

20. A method of supporting a test cartridge cell in an upright position by a test cartridge holder wherein the test cartridge cell has a plunger that extends from an upper open end of the cartridge cell, the plunger including a shaft having a first end and a second end, wherein a flag is disposed on the first end, the method comprising:

inserting the test cartridge cell into a test cartridge holder having a cartridge holder frame comprising a lower base and a rear frame configured to provide a test cartridge receptacle that receives and supports the cartridge cell in the upright position, the lower base having a fixed lower cartridge cell supporting and receiving structure that defines a lower portion of the upright position of the cartridge cell, and a plunger upper end deflector that defines a upper portion of the upright position of the cartridge cell and comprises a deflecting arm that extends at an angle from the rear frame over the lower cartridge cell supporting and receiving structure of the base to engage and deflect the plunger upper end of the cartridge cell when positioned in the upright position of the test cartridge receptacle;

while inserting the test cartridge cell into the test cartridge holder, deflecting the first end of the plunger from a central position as extending from the test cartridge cell toward a side of the test cartridge cell by engaging the first end of the plunger with the deflecting arm; and

dispensing a physiological sample into the cell.