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Hydrophilic vehicle-based dual controlled release matrix system

  • US 8,333,989 B2
  • Filed: 10/26/2006
  • Issued: 12/18/2012
  • Est. Priority Date: 10/26/2005
  • Status: Expired due to Fees
First Claim
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1. A capsule comprising a dual controlled release liquid matrix, the matrix comprising:

  • (a) a primary rate-controlling barrier comprising a hydrophilic vehicle;

    (b) a secondary rate-controlling barrier comprising a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle; and

    (c) a therapeutic, prophylactic or diagnostic agent dissolved or dispersed within the liquid matrix,wherein when the liquid matrix comes in contact with an aqueous medium, the hydrogel forming material forms a hydrogel suspended in the hydrophilic vehicle, andwherein the release of the therapeutic, prophylactic, or diagnostic agent is biphasic.

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