Hydrophilic vehicle-based dual controlled release matrix system
First Claim
1. A capsule comprising a dual controlled release liquid matrix, the matrix comprising:
- (a) a primary rate-controlling barrier comprising a hydrophilic vehicle;
(b) a secondary rate-controlling barrier comprising a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle; and
(c) a therapeutic, prophylactic or diagnostic agent dissolved or dispersed within the liquid matrix,wherein when the liquid matrix comes in contact with an aqueous medium, the hydrogel forming material forms a hydrogel suspended in the hydrophilic vehicle, andwherein the release of the therapeutic, prophylactic, or diagnostic agent is biphasic.
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Accused Products
Abstract
A hydrophilic vehicle-based dual controlled-release matrix system, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a solution or a suspension, which allows for easier formulation of low dose compounds. The matrix includes two rate controlling barriers for the controlled release of one or more pharmaceutically active agents. The primary rate controlling barrier includes a hydrophilic vehicle. The primary rate controlling barrier can further comprise one or more solvents which are miscible with the hydrophilic vehicle. The secondary rate controlling barrier includes a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle. The presence of the hydrogel-forming polymeric material makes extraction of the drug from the dosage form more difficult. This feature could be beneficial in preventing or minimizing the misuse of dosage forms which contain drugs which are prone to abuse.
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Citations
15 Claims
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1. A capsule comprising a dual controlled release liquid matrix, the matrix comprising:
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(a) a primary rate-controlling barrier comprising a hydrophilic vehicle; (b) a secondary rate-controlling barrier comprising a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle; and (c) a therapeutic, prophylactic or diagnostic agent dissolved or dispersed within the liquid matrix, wherein when the liquid matrix comes in contact with an aqueous medium, the hydrogel forming material forms a hydrogel suspended in the hydrophilic vehicle, and wherein the release of the therapeutic, prophylactic, or diagnostic agent is biphasic. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification