Boronate complex and its use in a glucose sensor

• US 8,334,140 B2
• Filed: 11/08/2006
• Issued: 12/18/2012
• Est. Priority Date: 11/08/2005
• Status: Expired due to Fees

• Current Assignee: Smart Holograms Ltd., Cambridge Enterprise Limited (University of Cambridge)
• Original Assignee: Smart Holograms Ltd., Cambridge Enterprise Limited (University of Cambridge)
• Inventors: Kabilan, Satyamoorthy, Lee, Mei-Ching, Horgan, Adrian Martin, Medlock, Kathryn Elizabeth Sorrell, Lowe, Christopher Robin, Blyth, Jeffrey
• Primary Examiner(s): YANG, NELSON C
• Application Number:
  US12/093,038
• Publication Number:
  US 20100167416A1
• Time in Patent Office: 2,232 Days
• Field of Search: None
• US Class Current: 436/95
• CPC Class Codes: G01N 21/453 Holographic interferometry for dimensional measurements G01B9/021 - G01B9/029
• CPC Class Codes: G01N 21/4788 Diffraction for sizing particles G01N15/0205
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G02B 5/32 Holograms used as optical elements
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose-binding boronate and a cationic species held within the sensor.

Claims

1. A holographic sensor comprising a holographic element and a matrix, wherein the matrix comprises a glucose-binding boronate and a quaternary ammonium compound.

2. The sensor according to claim 1, further comprising means for producing an interference effect when illuminated with laser light.

3. The sensor according to claim 2, wherein the means comprises a depolarising layer.

4. The sensor according to claim 1, which has an optical filter thereon.

5. The sensor according to claim 4, wherein the optical filter is a bandpass filter.

6. An article comprising a sensor according to claim 1, which is a test strip, chip, cartridge, swab, tube, pipette, contact lens, sub-conjunctival implant, sub-dermal implant, breathalyser, catheter or a fluid sampling or analysis device.

8. An article comprising a sensor according to claim 1, which is a transaction card, banknote, passport, identification card, smart card, driving license, share certificate, bond, cheque, cheque card, tax banderole, gift voucher, postage stamp, rail or air ticket, telephone card, lottery card, event ticket, credit or debit card, business card, or an item used in consumer, brand or product protection for the purpose of distinguishing genuine products from counterfeit products or identifying stolen products.

10. The sensor according to claim 1, wherein the quaternary ammonium compound comprises (3-acrylamidopropyl)trimethylammonium.

11. The sensor according to claim 1, wherein the glucose-binding boronate is 3-acrylamidophenylboronic acid.

12. The sensor according to claim 1, wherein at least one of the quaternary ammonium compound and the glucose-binding boronate is a monomer unit of the matrix.

7. A method of detection of an analyte in a sample, which comprises contacting the sample with the medium of a holographic sensor, and detecting any change of the optical characteristic wherein the sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a quaternary ammonium or phosphonium compound.

9. The method according to claim 7, wherein the analyte is a chemical, biochemical, or biological species.

21. The method according to claim 7, wherein the analyte comprises 2 cis-diol units.

22. The method according to claim 7, wherein the analyte is a monosaccharide or a disaccharide.

23. The method according to claim 7, wherein the analyte is glucose.

24. The method according to claim 7, wherein the change in optical characteristic is a shift in the color or image of the hologram.

25. The method according to claim 7, wherein the change in optical characteristic is a shift in the color of the hologram, and wherein the color of the hologram is in the visible range.

26. The method according to claim 25, wherein the shift in color is a reduction in the wavelength of an image of the hologram.

13. A holographic sensor comprising a holographic element and a matrix, wherein the matrix comprises a glucose-binding boronate and a quaternary phosphonium compound.

14. The sensor according to claim 13, further comprising means for producing an interference effect when illuminated with laser light.

15. The sensor according to claim 14, wherein the means comprises a depolarising layer.

16. The sensor according to claim 13, which has an optical filter thereon.

17. An article comprising a sensor according to claim 13, which is a test strip, chip, cartridge, swab, tube, pipette, contact lens, sub-conjunctival implant, sub-dermal implant, breathalyser, catheter or a fluid sampling or analysis device.

18. An article comprising a sensor according to claim 13, which is a transaction card, banknote, passport, identification card, smart card, driving license, share certificate, bond, cheque, cheque card, tax banderole, gift voucher, postage stamp, rail or air ticket, telephone card, lottery card, event ticket, credit or debit card, business card, or an item used in consumer, brand or product protection for the purpose of distinguishing genuine products from counterfeit products or identifying stolen products.

19. The sensor according to claim 13, wherein the glucose-binding boronate is 3-acrylamidophenylboronic acid.

20. The sensor according to claim 13, wherein at least one of the quaternary phosphonium compound and the glucose-binding boronate is a monomer unit of the matrix.