Method and apparatus for instrument placement
First Claim
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1. A method of determining a delivery location within a volume, comprising:
- selecting a physical region within the volume for a drug delivery;
determining a volume of efficacy for the drug within the physical region where the delivered drug achieves a tissue concentration to elicit a meaningful physiological effect in the selected physical region;
acquiring image data of the volume;
determining an image region of therapy in the image data that is the physical region within the image data; and
determining an optimized delivery point within the selected physical region to achieve the volume of efficacy wherein determining an optimized delivery point includes operating a processor to execute instructions for;
identifying a plurality of points within the image region of therapy and a plurality of line segments radially extending from each point of the plurality of points,measuring a length of each line segment of the plurality of line segments from each point,assigning a weight to each line segment based at least on a location of a second end of each line segment relative to at least one of a border of the image region of therapy or a structure in the image data,determining a weighted average length of the plurality of line segments extending from each point, andoutputting the optimized delivery point based on the determined weighted average of the line segments extending from each point.
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Abstract
When delivering a therapy to a patient, such as a drug to a brain of a patient, an optimized delivery point can be selected. The optimized point can be based on physics, physiology, and pharmacology. The optimized point can be used for planning a surgical navigation procedure.
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Citations
28 Claims
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1. A method of determining a delivery location within a volume, comprising:
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selecting a physical region within the volume for a drug delivery; determining a volume of efficacy for the drug within the physical region where the delivered drug achieves a tissue concentration to elicit a meaningful physiological effect in the selected physical region; acquiring image data of the volume; determining an image region of therapy in the image data that is the physical region within the image data; and determining an optimized delivery point within the selected physical region to achieve the volume of efficacy wherein determining an optimized delivery point includes operating a processor to execute instructions for; identifying a plurality of points within the image region of therapy and a plurality of line segments radially extending from each point of the plurality of points, measuring a length of each line segment of the plurality of line segments from each point, assigning a weight to each line segment based at least on a location of a second end of each line segment relative to at least one of a border of the image region of therapy or a structure in the image data, determining a weighted average length of the plurality of line segments extending from each point, and outputting the optimized delivery point based on the determined weighted average of the line segments extending from each point. - View Dependent Claims (2, 3, 4, 5, 6, 7, 23, 24)
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8. A method of determining an optimized location for delivering a compound of interest within a brain, comprising:
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selecting a physical region within the brain for the compound of interest delivery; selecting an instrument for the compound of interest delivery; determining a volume of efficacy for the compound of interest, including evaluating the interaction of the compound of interest within the selected physical region within the brain; acquiring image data of the brain; identifying an image region of therapy that is a representation in the acquired image data of the selected physical region; and determining at least a single optimized delivery point within the image region of therapy to achieve the volume of efficacy at least within a portion of the selected physical region, including operating a processor to automatically execute instructions after identifying the image region of therapy, wherein the instructions include; identifying a plurality of points within the image region of therapy; determining a plurality of line segments radially extending from each point of the plurality of points to at least one of a surface of the image region of therapy or structures outside of the image region of therapy; measuring a length of each line segment; and determining an average length of the plurality of line segments extending from each point; wherein the single optimized delivery point is based at least on the determined average length of the plurality of line segments extending from each point, and superimposing at least the determined single optimized delivery point as an icon on the acquired image data. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 25, 26, 27)
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18. A system to determine a delivery location within a volume, comprising:
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a storage system operable to store acquired image data of the volume; an input device operable to input a selected physical region within the volume for compound of interest delivery; an instrument configured to be positioned within the volume to deliver the compound of interest; a processor operable to execute instructions to identify an image region of therapy that is a representation of the selected physical region, wherein the processor is further operable to execute instructions to determine an optimized delivery point within the image region of therapy to position at least a portion of the instrument to achieve a volume of efficacy at least within a portion of the selected physical region, wherein the instructions include; identifying a plurality of points within the image region of therapy; determining a plurality of line segments radially extending from each point of the plurality of points to at least one of a surface of the image region of therapy or structures outside of the image region of therapy; measuring a length of each line segment; and determining an average length of the plurality of line segments extending from each point; wherein the optimized delivery point is based at least on the determined average length of the plurality of line segments extending from each point; and an output device operable to output the determined optimized delivery point relative to the acquired image data. - View Dependent Claims (19, 20, 21, 22, 28)
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Specification