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Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution for hemodialysis

  • US 8,337,444 B2
  • Filed: 05/03/2007
  • Issued: 12/25/2012
  • Est. Priority Date: 05/22/2001
  • Status: Active Grant
First Claim
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1. A system for determining non-invasively at least one cardiovascular parameter of a patient undergoing hemodialysis comprising:

  • a) a dialyzer configured to perform hemodialysis on the patient, wherein the hemodialysis comprises blood removal from and administration of a fluorescent dye to the cardiovascular system of the patient;

    b) a probe assembly comprising;

    i) an optical illumination source configured to illuminate the removed blood having the administered fluorescent dye with a first wavelength of light, wherein the illumination causes the fluorescent dye to emit light of a second wavelength, wherein the second wavelength is different than the first wavelength; and

    ii) at least one optical detector configured to detect the intensity of light, having the second wavelength, that is emitted from the illuminated fluorescent dye, and configured to send a corresponding electronic signal;

    c) a processor configured to receive the sent electronic signal and to estimate at least one cardiovascular parameter of the patient based on the sent electronic signal;

    wherein the processor is configured to correct the estimation of the at least one cardiovascular parameter for changes in the blood hematocrit or hemoglobin content of the patient undergoing hemodialysis; and

    d) a monitoring system configured to monitor the estimated cardiovascular parameter during hemodialysis.

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