Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution for hemodialysis
First Claim
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1. A system for determining non-invasively at least one cardiovascular parameter of a patient undergoing hemodialysis comprising:
- a) a dialyzer configured to perform hemodialysis on the patient, wherein the hemodialysis comprises blood removal from and administration of a fluorescent dye to the cardiovascular system of the patient;
b) a probe assembly comprising;
i) an optical illumination source configured to illuminate the removed blood having the administered fluorescent dye with a first wavelength of light, wherein the illumination causes the fluorescent dye to emit light of a second wavelength, wherein the second wavelength is different than the first wavelength; and
ii) at least one optical detector configured to detect the intensity of light, having the second wavelength, that is emitted from the illuminated fluorescent dye, and configured to send a corresponding electronic signal;
c) a processor configured to receive the sent electronic signal and to estimate at least one cardiovascular parameter of the patient based on the sent electronic signal;
wherein the processor is configured to correct the estimation of the at least one cardiovascular parameter for changes in the blood hematocrit or hemoglobin content of the patient undergoing hemodialysis; and
d) a monitoring system configured to monitor the estimated cardiovascular parameter during hemodialysis.
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Abstract
A system and method of non-invasive or minimally invasive evaluating the cardiovascular system parameters to estimate the cardiac output and circulating blood volume of a patient undergoing hemodialysis. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health before and during hemodialysis.
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Citations
24 Claims
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1. A system for determining non-invasively at least one cardiovascular parameter of a patient undergoing hemodialysis comprising:
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a) a dialyzer configured to perform hemodialysis on the patient, wherein the hemodialysis comprises blood removal from and administration of a fluorescent dye to the cardiovascular system of the patient; b) a probe assembly comprising; i) an optical illumination source configured to illuminate the removed blood having the administered fluorescent dye with a first wavelength of light, wherein the illumination causes the fluorescent dye to emit light of a second wavelength, wherein the second wavelength is different than the first wavelength; and ii) at least one optical detector configured to detect the intensity of light, having the second wavelength, that is emitted from the illuminated fluorescent dye, and configured to send a corresponding electronic signal; c) a processor configured to receive the sent electronic signal and to estimate at least one cardiovascular parameter of the patient based on the sent electronic signal;
wherein the processor is configured to correct the estimation of the at least one cardiovascular parameter for changes in the blood hematocrit or hemoglobin content of the patient undergoing hemodialysis; andd) a monitoring system configured to monitor the estimated cardiovascular parameter during hemodialysis. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification