Device and methods for treating paranasal sinus conditions

• US 8,337,454 B2
• Filed: 05/07/2009
• Issued: 12/25/2012
• Est. Priority Date: 04/04/2005
• Status: Active Grant

• Current Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Original Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Inventors: Eaton, Donald J., Tice, Thomas R., Downie, David B., Arensdorf, Patrick A., Brenneman, Rodney, Biggs, Danielle L.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): MEDWAY, SCOTT J
• Application Number:
  US12/437,374
• Publication Number:
  US 20090227945A1
• Time in Patent Office: 1,328 Days
• Field of Search: 604/101.01, 604/514, 604/94.01, 606/199
• US Class Current: 604/94.01
• CPC Class Codes: A61B 17/24 for use in the oral cavity, larynx, bronchial passages or nose for medical inspection of cavities or tubes in the body A61B1/00; Tongue scrapers
• CPC Class Codes: A61F 2/186 Nose parts
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61M 29/00 Dilators with or without means for introducing media, e.g. remedies instruments for performing visual medical inspections of cavities or tubes of the body A61B1/00
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.

Claims

1. A fully-implantable, bioabsorbable device for treating a nasal or paranasal sinus condition comprising:

a tubular member having a proximal end and a distal end;

a first plurality of prongs attached to the tubular member at the proximal end thereof, each prong having a free end; and

a second plurality of prongs attached to the tubular member at the distal end thereof, each prong having a free end,

wherein the device has an expanded configuration and an unexpanded configuration, and wherein the first plurality of prongs expands relative to the tubular member when the device changes from the unexpanded configuration to the expanded configuration.

2. The device of claim 1 wherein the first plurality of prongs are radially expandable.

3. The device of claim 2 wherein the first plurality of prongs are self-expandable.

4. The device of claim 1 further comprising one or more active agents.

5. The device of claim 4 wherein the one or more active agents comprises mometasone furoate.

6. The device of claim 4 wherein the one or more active agents comprises fluticasone propionate.

7. The device of claim 4 wherein the one or more active agents comprises triamcinolone acenotide.

8. The device of claim 1 wherein the device is biodegradable.

9. The device of claim 1 wherein the device comprises a polymer.

10. The device of claim 9 wherein the device comprises poly(lactic acid-co-glycolic acid).

11. The device of claim 1 wherein the plurality of prongs comprises prongs between about 1 cm and about 6 cm in length.

12. The device of claim 1 wherein the device is injection molded.

13. A fully-implantable, bioabsorbable device for treating a nasal or paranasal sinus condition comprising:

a tubular member having a proximal end and a distal end;

a first plurality of prongs having proximal and free distal ends; and

a second plurality of prongs, each prong having a free end,

wherein the proximal ends of the first plurality of prongs are attached to the tubular member at the proximal end thereof, wherein the device has an expanded configuration and an unexpanded configuration, wherein the first plurality of prongs expands relative to the tubular member when the device expands from the unexpanded configuration to the expanded configuration, wherein the free distal ends of the first plurality are spaced apart when the device is in its expanded configuration, and wherein the second plurality of prongs are attached to the tubular member at the distal end thereof.