Methods and apparatus for delivering ocular implants into the eye

• US 8,337,509 B2
• Filed: 12/07/2009
• Issued: 12/25/2012
• Est. Priority Date: 11/20/2007
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Ivantis Inc. (Alcon Incorporated)
• Inventors: Schieber, Andrew T., Matthees, Edward, Euteneuer, Charles L., Wardle, John L
• Primary Examiner(s): Houston, Elizabeth
• Assistant Examiner(s): MILES, JONATHAN WADE
• Application Number:
  US12/632,738
• Publication Number:
  US 20100121342A1
• Time in Patent Office: 1,114 Days
• Field of Search: 606/107, 606/108, 623/1.11, 623/1.23, 623/6.12, 604/272, 604/273, 604/274
• US Class Current: 606/108
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008

Abstract

A cannula for an ocular implant delivery system. In some embodiments, the cannula includes a tubular member having a curved portion, a distal opening surrounded by a distal opening surface, and a distal tip, the distal tip being adapted to be inserted into an anterior chamber of a human subject'"'"'s eye, through trabecular meshwork and into Schlemm'"'"'s canal of the eye, a proximal portion of the tubular member being adapted to extend from a location exterior to the eye when the distal tip is in Schlemm'"'"'s canal of the eye, the cannula being further adapted to cooperate with an advancement mechanism to advance an ocular implant through the tubular member toward and through the distal opening into Schlemm'"'"'s canal of the eye when the distal tip is disposed in Schlemm'"'"'s canal. The invention also includes a method of deploying an ocular implant into Schlemm'"'"'s canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm'"'"'s canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm'"'"'s canal and an inlet portion of the ocular implant in the anterior chamber.

Claims

1. An ocular implant system comprising:

an ocular implant comprising an inlet sized and configured to be disposed in an anterior chamber of a human subject'"'"'s eye and a body sized and configured to be disposed in Schlemm'"'"'s canal of the eye when the inlet is disposed in the anterior chamber, the ocular implant being adapted to bend preferentially in a preferential bending plane; and

a delivery cannula comprising a tubular member comprising a distal curved portion, a distal opening surrounded by a distal opening surface, a distal sharp portion and a distal tip, the distal sharp portion being adapted to be inserted into an anterior chamber of a human subject'"'"'s eye, through trabecular meshwork and into Schlemm'"'"'s canal of the eye by piercing the trabecular meshwork and a wall of Schlemm'"'"'s canal, the tubular member being adapted to extend from a location exterior to the eye when the distal tip is in Schlemm'"'"'s canal of the eye, the cannula being further adapted to cooperate with an advancement mechanism to advance the ocular implant through at least the curved portion of the tubular member toward and through the distal opening into Schlemm'"'"'s canal of the eye when the distal tip of the delivery tool is disposed in Schlemm'"'"'s canal.

2. The ocular implant system of claim 1 wherein a central axis of the cannula defines a cannula curvature plane, the ocular implant being oriented within the cannula so that the implant preferential bending plane is co-planar with the cannula curvature plane.

3. The cannula of claim 1 wherein the distal curved portion has a smaller radius of curvature than Schlemm'"'"'s canal.

4. The cannula of claim 3 wherein the tubular member further comprises a tongue region extending proximally from the distal tip on one side of the tubular member, the tongue region forming at least part of the distal opening surface such that the distal opening surface is more distal on the one side than on a side of the tubular member opposite to the one side.

5. The cannula of claim 4 wherein the tubular member further comprises a second tongue region and a stop member defining the distal opening surface.

6. The cannula of claim 3 wherein the distal opening surface is disposed in a distal opening plane and the tubular member curved portion defines a curve plane, and the distal opening plane is at an angle other than 90 degrees with respect to the curve plane.

7. The cannula of claim 3 wherein the curved portion of the tubular member has a bend angle between 105 degrees and 165 degrees.

8. The cannula of claim 1 wherein the cannula distal opening has a diameter greater than a diameter of Schlemm'"'"'s canal.

9. The cannula of claim 8 wherein the tubular member further comprises a tongue region extending proximally from the distal tip on one side of the tubular member, the tongue region forming at least part of the distal opening surface such that the distal opening surface is more distal on the one side than on a side of the tubular member opposite to the one side.

10. The cannula of claim 9 wherein the tubular member further comprises a second tongue region and a stop member defining the distal opening surface.

11. The cannula of claim 8 wherein the distal opening surface is disposed in a distal opening plane and the tubular member curved portion defines a curve plane, and the distal opening plane is at an angle other than 90 degrees with respect to the curve plane.

12. The cannula of claim 8 wherein the curved portion of the tubular member has a bend angle between 105 degrees and 165 degrees.