Method and device for closing holes in tissue

• US 8,337,524 B2
• Filed: 05/11/2010
• Issued: 12/25/2012
• Est. Priority Date: 02/21/2006
• Status: Active Grant

• Current Assignee: Kardium Inc.
• Original Assignee: Kardium Inc.
• Inventors: Gelbart, Daniel, Lichtenstein, Samuel Victor
• Primary Examiner(s): Tyson, Melanie
• Assistant Examiner(s): DANG, PHONG SON H
• Application Number:
  US12/777,883
• Publication Number:
  US 20100222789A1
• Time in Patent Office: 959 Days
• Field of Search: 606/213, 606/216, 606142-143
• US Class Current: 606/216
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/00575 for closure at remote site, e.g. closing atrial septum defects
• CPC Class Codes: A61B 2017/00579 Barbed implements
• CPC Class Codes: A61B 2017/00584 Clips
• CPC Class Codes: A61B 2017/00592 Elastic or resilient implements
• CPC Class Codes: A61B 2017/00615 Implements with an occluder on one side of the opening and holding means therefor on the other
• CPC Class Codes: A61B 2017/00623 Introducing or retrieving devices therefor
• CPC Class Codes: A61B 2017/00637 for sealing trocar wounds through abdominal wall
• CPC Class Codes: A61B 2017/00862 elastic or resilient
• CPC Class Codes: A61B 2017/22061 for spreading elements apart

Abstract

A device for closing holes in tissue is delivered via a catheter to the inside of a body lumen such as a heart. An elastic barbed clip is expanded, pulled into the tissue and released, pulling the tissue with it. The operation is fully reversible.

Claims

1. A method of closing a hole in a tissue internally in a body, the method comprising:

inserting an elongated tool carrying a clip having a plurality of tissue piercing tips into the body, the elongated tool having at least one actuator that protectively retains each of the tissue piercing tips as the clip is delivered in a retracted configuration through the hole in the tissue from a first side of the tissue to a second side of the tissue;

manipulating the elongated tool to cause the clip to move into an expanded configuration in which the tissue piercing tips are positioned about the tissue that encompasses the hole in the tissue with the tissue piercing tips protectively retained by the at least one actuator;

manipulating the elongated tool to cause the tissue piercing tips of the clip to become exposed after the tissue piercing tips are positioned about the tissue that encompasses the hole in the tissue;

embedding the exposed tissue piercing tips into the tissue from the second side of the tissue with at least some of the tissue piercing tips opposed to one another across the hole;

further manipulating the elongated tool to cause the clip to move from the expanded configuration toward the retracted configuration and to cause the exposed tissue piercing tips to further embed into the tissue;

releasing the clip from the elongated tool; and

removing the elongated tool from the body.

2. The method of claim 1, further comprising:

inserting a catheter into the body, wherein the inserting the elongated tool carrying the clip having the plurality of tissue piercing tips into the body comprises inserting the elongated tool carrying the clip into the body via the catheter.

3. The method of claim 1 wherein releasing the clip from the elongated tool includes rotating a rod of the elongated tool to unthread the clip from a threaded distal end of the rod.

4. The method of claim 1, further comprising:

retrieving the clip from the body with the elongated tool.

5. The method of claim 1 wherein the embedding the exposed tissue piercing tips into the tissue comprises pulling a portion of the elongated tool outward toward the first side of the tissue.

6. The method of claim 1, further comprising:

reattaching the clip to the elongated tool after the clip has been detached therefrom.

7. The method of claim 6, further comprising:

removing the tissue piercing tips of the clip from the second side of the tissue in response to a portion of the elongated tool being pushed from the first side of the tisssue toward the second side of the tissue.

8. The method of claim 7, further comprising:

protectively receiving the tissue piercing tips of the clip by the at least one actuator after the clip has been reattached to the elongated tool.

9. A method of closing holes in tissue internally in bodies, the method comprising:

inserting an elongated tool carrying a clip having a plurality of tissue piercing tips into a body, the elongated tool having at least one actuator that protectively retains each of the tissue piercing tips as the clip is delivered through a hole in tissue in a retracted configuration;

manipulating the elongated tool to move the clip into an expanded configuration in which the tissue piercing tips are positioned about the tissue that encompasses the hole in the tissue and are protectively retained by the at least one actuator;

activating the at least one actuator to expose the tissue piercing tips after the tissue piercing tips are positioned about the tissue that encompasses the hole in the tissue;

releasing the clip from the elongated tool; and

removing the elongated tool from the body.

10. The method of claim 9, further comprising:

manipulating the elongated tool to-cause the clip to move from the expanded configuration toward the retracted configuration after the at least some of the exposed tissue piercing tips are embedded into the tissue.

11. The method of claim 9 wherein inserting the elongated tool carrying the clip having the plurality of tissue piercing tips into the body comprises inserting the elongated tool from a first side of the tissue toward a second side of the tissue, and wherein the tissue piercing tips embed in the tissue from the second side.