Implant and system of an implant and an excitation device

• US 8,337,548 B2
• Filed: 07/11/2008
• Issued: 12/25/2012
• Est. Priority Date: 07/13/2007
• Status: Active Grant

• Current Assignee: Biotronik AG (Biotronik SE & Company KG)
• Original Assignee: Biotronik VI Patent AG (Biotronik SE & Company KG)
• Inventors: Klocke, Bjoern, Fringes, Matthias, Hofmann, Eugen
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): Woznicki, Jacqueline
• Application Number:
  US12/171,566
• Publication Number:
  US 20090017088A1
• Time in Patent Office: 1,628 Days
• Field of Search: 623/1.42
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2210/0071 thermoplastic
• CPC Class Codes: A61F 2250/0001 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

An implant comprising a body (1), at least one active pharmaceutical substance (4) and an element (5, 15, 35, 45, 55) deflectable in relation to the body, serving to release the at least one active pharmaceutical substance (4) during or after an external excitation of the deflection. Also disclosed is a system of such an implant and an excitation device (30, 70).

Claims

1. An implant, comprising:

a) a body;

b) at least one recess formed in the body, the recess adapted to retain at least one active pharmaceutical substance;

each of the at least one recesses having;

an opening providing access to the at least one recess; and

a deflectable element having an upper surface portion and a lower surface portion and disposed within the at least one recess such that the at least one pharmaceutical substance is in contact with either or both the upper and lower surfaces of the deflectable element when the level of pharmaceutical substance is at its maximum, the deflectable element being at least partially either ferromagnetic or permanently magnetic, the deflectable element being displaceable by vibration in response to an excitation signal from a resting first state which does not allow the at least one pharmaceutical substance to move from the at least one recess through the opening, to a vibrating second state, the vibrating second state causing agitation of the at least one active pharmaceutical substance from the at least one recess through the opening or movement of the at least one active pharmaceutical substance from the at least one recess through the opening, wherein in response to the removal of the excitation signal the deflectable element returns to the resting first state which can thereafter again be excited into the vibrating second state.

2. The implant of claim 1, wherein each deflectable element is repeatedly cyclable between the resting first state and excited second state in response to the application or nonapplication of the excitation signal.

3. The implant of claim 1, wherein a frequency of an external excitation signal is coordinated with the deflectable element so that the vibration of the deflectable element is at a resonant frequency.

4. The implant of claim 1, wherein a geometry or a mass of the deflectable element is coordinated with a frequency of an external excitation signal, so that vibration of the deflectable element is at a resonant frequency.

5. The implant of claim 1, wherein an external excitation takes place by means of a signal of an alternating magnetic field.

6. The implant of claim 1, wherein the deflectable element is plate-shaped and has at least one opening.

7. The implant of claim 1, wherein the body includes a layer that comprises a degradable film.

8. The implant of claim 1, wherein the deflectable element is provided in a recess in the body, whereby the at least one active pharmaceutical substance is arranged above or below the deflectable element.

9. The implant of claim 8, wherein the deflectable element has openings which are closed in a state without external excitation and are temporarily open in a state with external excitation and thereby release the at least one active pharmaceutical substance.

10. The implant of claim 8, wherein the deflectable element is arranged in an opening passing through the body, the opening being closed on one side by a semipermeable membrane and closed on another side by an impermeable plastic cover, whereby the deflectable element and the at least one active pharmaceutical substance are provided between the semipermeable membrane and the plastic cover in the opening.

11. The implant of claim 10, wherein the semipermeable membrane has a pore size between approximately 0.5 μ

m and approximately 1 μ

m.