Devices and methods for tissue engineering
First Claim
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1. A resorbable three-dimensional tissue scaffold comprising:
- bioactive glass fibers;
bioactive glass bonding to at least a portion of the bioactive glass fibers; and
pore space within the three-dimensional tissue scaffold by volatile components removed during the bioactive glass bonding to the bioactive glass fibers,wherein the pore space creates a porosity between about 40% and about 85% in the resorbable three-dimensional tissue scaffold.
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Abstract
A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.
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Citations
14 Claims
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1. A resorbable three-dimensional tissue scaffold comprising:
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bioactive glass fibers; bioactive glass bonding to at least a portion of the bioactive glass fibers; and pore space within the three-dimensional tissue scaffold by volatile components removed during the bioactive glass bonding to the bioactive glass fibers, wherein the pore space creates a porosity between about 40% and about 85% in the resorbable three-dimensional tissue scaffold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A bioactive tissue scaffold comprising:
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a rigid three-dimensional matrix of a bioactive composition formed from a process comprising; mixing a bioactive fiber, a binder, a bioactive glass powder bonding agent, a pore former, and a liquid into a plastically formable batch; forming the plastically formable batch into a shaped object; drying the shaped object to remove the liquid; removing the binder; removing the pore former; and heating the shaped object to fuse and bond the bioactive fiber into the rigid three-dimensional matrix using the bioactive glass powder bonding agent with pore space defined by the pore former. - View Dependent Claims (10, 11, 12, 13, 14)
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Specification