Glucagon analogs exhibiting physiological solubility and stability
First Claim
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1. A derivative of native glucagon (SEQ ID NO:
- 1) comprising a hydrophilic moiety covalently bound to a residue at position 16, 17, or 21, of the derivative, wherein the peptide stimulates activity at the glucagon receptor, and pharmaceutically acceptable salts of said derivative.
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Abstract
Modified glucagon peptides are disclosed having improved solubility and stability, wherein the native glucagon peptide has been modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, or both.
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Citations
15 Claims
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1. A derivative of native glucagon (SEQ ID NO:
- 1) comprising a hydrophilic moiety covalently bound to a residue at position 16, 17, or 21, of the derivative, wherein the peptide stimulates activity at the glucagon receptor, and pharmaceutically acceptable salts of said derivative.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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