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Packaged product

  • US 8,338,375 B2
  • Filed: 12/29/2009
  • Issued: 12/25/2012
  • Est. Priority Date: 05/23/2007
  • Status: Active Grant
First Claim
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1. A packaged product useful for dermal correction and sculpting comprising:

  • a syringe; and

    an injectable dermal filler composition in the syringe, the composition comprising a cross-linked collagen prepared by the steps ofincubating collagen selected from a group consisting of type I collagen, type II collagen, type III collagen, type IV collagen, type V collagen, telo-containing collagen, atelo-collagen, derivatized collagen, and a combination thereof, in a suspension or solution having pH in the range of pH 2-5 or pH 9-12,treating said collagen with a cross-linking agent selected from the group consisting of carbodiimides, polyaldehydes, polysulfones, activated PEGs, epoxides, imidazoles and diisocyanates at pH 2-5 or pH 9-12, andisolating the cross-linked collagen to thereby obtain the composition,wherein the cross-linked collagen is in a gel but not in a fibrous state.

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