Modulators of toll-like receptor 7

• US 8,338,593 B2
• Filed: 07/06/2007
• Issued: 12/25/2012
• Est. Priority Date: 07/07/2006
• Status: Active Grant

• Current Assignee: Gilead Sciences Inc.
• Original Assignee: Gilead Sciences Inc.
• Inventors: Chong, Lee S., Desai, Manoj C., Gallagher, Brian, Graupe, Michael, Halcomb, Randall L., Yang, Hong, Zhang, Jennifer R.
• Primary Examiner(s): BERCH, MARK L
• Application Number:
  US12/303,214
• Publication Number:
  US 20090202484A1
• Time in Patent Office: 1,999 Days
• Field of Search: 544/157, 544/244, 514/81
• US Class Current: 544/157
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: A61P 31/20 for DNA viruses
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07F 9/65616 containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Abstract

The present application provides for a compound of Formula (I) or (II): or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.

Claims

1. A compound selected from the group consisting of: